Expert Review of Molecular Diagnostics ( IF 5.1 ) Pub Date : 2020-12-04 , DOI: 10.1080/14737159.2020.1847647 Xiao Du 1, 2 , Shilan Zhang 1, 2 , Jin Xu 1, 2 , Qunyan Xiang 1, 2 , Feng Tian 1, 2 , Xin Li 1, 2 , Liling Guo 1, 2 , Liyuan Zhu 1, 2 , Peiliu Qu 1, 2 , Yan Fu 1, 2 , Yangrong Tan 1, 2 , Yajun Gui 1, 2 , Tie Wen 3 , Brianna Godinez 4 , Ling Liu 1, 2
ABSTRACT
Background: Recently, considerable evidence pointed out monocyte to high-density lipoprotein ratio (MHR) is highly related to inflammatory related diseases. We aim to explore the level of MHR in acute aortic dissection (AAD) patients and determine whether MHR can be a novel diagnostic marker of AAD.
Research design and methods: A total of 228 subjects including 128 AAD patients and 110 healthy control were enrolled. MHR levels and other serum samples were obtained at admission.
Results: The baseline MHR levels were significantly higher in patients with AAD (p < 0.0001). A cutoff value of MHR >0.37 was associated with a sensitivity of 86.70% and a specificity of 93.60% for AAD. MHR levels were positively correlated with the time from symptom onset (R2 = 0.0318, p = 0.0003). Additionally, the area under the curve (AUC) was increased to 0.979 in patients whose time from onset of symptoms >24 h, with a sensitivity of 98.04% and a specificity of 93.64%. Multivariate logistic regression demonstrated that MHR levels, history of hypertension, and coronary artery disease (CHD) emerged as independent predictors of AAD.
Expert Opinion: MHR has a high diagnostic value in AAD patients, especially in those whose time from onset of symptoms >24 h.
京公网安备 11010802027423号