ABSTRACT

We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-α and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties.

摘要

我们研究了木犀草素 (LUT) 治疗对盲肠结扎和穿刺 (CLP) 诱导的脓毒症大鼠引起的急性肺损伤的影响。我们还研究了 LUT 与细胞因子、白细胞介素-10 (IL-10) 和肿瘤坏死因子-α (TNF-α) 之间的关系。LUT 在 CLP 手术后 1 小时进行。LUT 的施用降低了大鼠肺组织中的谷胱甘肽水平和超氧化物歧化酶活性。我们还发现 LUT 治疗后丙二醛显着减少。LUT 给药还降低了肺组织中 TNF-α 和 IL-10 mRNA 的表达。肺组织的组织病理学研究支持了我们的生化和分子发现。由于其抗氧化和抗炎特性，LUT 的给药可改善 CLP 诱导的败血症大鼠的肺损伤。