Limited literature is available on stimulus induced after discharges (SIAD) in patients with peripheral nerve hyperexcitability (PNH). The aim of the study was to examine the diagnostic utility of SIAD in the diagnosis and monitoring of primary PNH disorders. In this retrospective study, we studied 26 patients who were admitted with a diagnosis of primary PNH to the department of Neurology from January 2013 to April 2019. Their clinical profile, immunological characteristics were extracted from the database and nerve conduction studies were relooked for the presence of SIAD. 76% of patients in the primary PNH cohort had SIAD with 90% of them being voltage‐gated potassium channel complex antibody positive; predominantly against contactin‐associated protein‐2 antigen and rest being paraneoplastic. There was also resolution of SIAD following treatment indicating reversible hyperexcitability. SIAD is a sensitive marker for Primary PNH syndrome with monitoring and diagnostic implications.

中文翻译：

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放电后刺激在评估周围神经过度兴奋中的效用：新瓶装旧酒？

关于周围神经过度兴奋 (PNH) 患者出院后诱发刺激 (SIAD) 的文献有限。该研究的目的是检查 SIAD 在诊断和监测原发性 PNH 疾病中的诊断效用。在这项回顾性研究中，我们研究了 26 名于 2013 年 1 月至 2019 年 4 月被神经内科诊断为原发性 PNH 的患者。从数据库中提取了他们的临床特征、免疫学特征，并重新寻找神经传导研究的存在SIAD。主要 PNH 队列中 76% 的患者患有 SIAD，其中 90% 为电压门控钾通道复合物抗体阳性；主要针对接触相关蛋白 2 抗原，其余为副肿瘤性。治疗后 SIAD 也消退，表明可逆的过度兴奋。SIAD 是原发性 PNH 综合征的敏感标志物，具有监测和诊断意义。