Correct 3D genome organization is essential for the proper functioning of the genome. Recent advances in image-based 3D genomics techniques have enabled direct tracing of chromatin folding and multiplexed imaging of nucleome architectures in single cells of several important biological systems. Here, we discuss these advances and the future directions of image-based 3D genomics.

中文翻译：

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染色质追踪：3D 基因组和核组成像

正确的 3D 基因组组织对于基因组的正常运作至关重要。基于图像的 3D 基因组学技术的最新进展已经能够在几个重要生物系统的单细胞中直接追踪染色质折叠和核组结构的多重成像。在这里，我们将讨论这些进展以及基于图像的 3D 基因组学的未来方向。