Abstract

Eight new furan derivatives, irpexins A‒H (1‒8), two new polyketides, irpexins I and J (9 and 10), together with nine known compounds were isolated from the fermentation of Irpex lacteus. The structures and absolute configurations were elucidated on the basis of extensive spectroscopic methods and Mosher ester reaction. All compounds shows no cytotoxicity to human MCF-7 and Hela cancer cell lines at the concentration of 10 μM.

Graphic Abstract

中文翻译：

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真菌Irpex lacteus的呋喃衍生物和聚酮化合物

摘要

八个新呋喃衍生物，irpexins A-H（1 - 8），两个新的聚酮化合物，irpexins I和J（9和10），加上9种已知化合物从发酵中分离白耙齿菌。在广泛的光谱学方法和Mosher酯反应的基础上阐明了结构和绝对构型。在浓度为10μM时，所有化合物对人MCF-7和Hela癌细胞系均无细胞毒性。

图形摘要