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Unusual Correlation between Rest–Activity and Body Temperature Rhythms in the Naked Mole Rat ( Heterocephalus glaber ) as Compared to Five Other Mammalian Species
Journal of Evolutionary Biochemistry and Physiology ( IF 0.6 ) Pub Date : 2020-11-12 , DOI: 10.1134/s0022093020050087
V. M. Kovalzon , O. A. Averina , V. A. Minkov , A. A. Petrin , M. Yu. Vysokikh

Abstract

Body temperature and locomotor activity were recorded over a month using intraperitoneal sensors in the following six mammalian species: naked mole rats (Heterocephalus glaber, 2♂, 2♀), C57Bl/6j mice (6♂), outbred white rats (4♂), Mongolian hamsters (Allocricetulus curtatus, 3♂), sables (Martes zibellina, 2♂, 2♀), forest ferrets (Mustela putorius, 2♂, 2♀). During experiments, the naked mole rats stayed in their colony under special laboratory conditions: 2 weeks in constant darkness (dim red light), 2 weeks under an alternating light–dark regime (12L/12D). Mice and rats were kept in individual chambers under standard laboratory conditions and a 12L/12D regime; sables and ferrets were kept in their outdoor enclosures under natural light conditions in autumn. All the rodents used in the experiments, except for mole rats, are nocturnal animals. Accordingly, all of them showed a clear circadian rest–activity rhythm: a high level of locomotor activity in the daytime and low at night. The body temperature rhythm showed a synphase correlation with the rest–activity rhythm: temperature rose at night and fell in the daytime (0.9 < r < 1). At the same time, in hamsters, an increase in locomotor activity at night, when the ambient temperature went down, was accompanied by a corresponding increase in the amplitude of body temperature elevations. Small predators, sables and ferrets, demonstrated a more smoothed circadian rhythm. In contrast to all these species, body temperature of mole rats dropped sharply by 3–5°С (down to 28°С) upon activation of their locomotor activity (usually in the morning and evening hours) and jumped (up to 36°С) at rest (in the night hours) both under constant darkness and 12L/12D regime (–0.7 < r < –0.9). Overall, these animals showed an original thermoregulatory system with a possible “set point” at about 33.5°C.



中文翻译:

与其他五个哺乳动物物种相比,裸Mo鼠(Heterocephalus glaber)的休息活动与体温节律之间的异常相关性

摘要

在以下六个哺乳动物物种中,使用腹膜内传感器记录了一个月内的体温和运动能力:裸mole鼠(Heterocephalus glaber,2♂,2♀),C57Bl / 6j小鼠(6♂),近交白鼠(4♂) ,蒙古仓鼠(Allocricetulus curtatus,3♂),黑貂(Martes zibellina,2♂,2♀),森林雪貂(Mustela putorius,2♂,2♀)。在实验过程中,裸mole鼠在特殊的实验室条件下停留在其菌落中:在持续的黑暗中(暗红色)2周,在交替的明暗关系下(12L / 12D)2周。将小鼠和大鼠在标准实验室条件和12L / 12D方案下关在单独的隔间中。在秋天,黑貂和雪貂在自然光线下被保存在室外的围栏中。除mole鼠外,实验中使用的所有啮齿动物均为夜间活动动物。因此,他们所有的人都显示出清晰的昼夜节律活动节律:白天运动活动水平高,晚上低。体温节律与休息活动节律呈同相相关性:夜间温度升高,白天温度降低(0.9 < r<1)。同时,在仓鼠中,当环境温度下降时,夜间自发活动的增加伴随着体温升高幅度的相应增加。小型食肉动物,黑貂和雪貂表现出较平稳的昼夜节律。与所有这些物种相反,mole鼠的运动能力激活后(通常在早晨和傍晚),mole鼠的体温急剧下降3-5°С(降至28°С),然后跃升(高达36°С)。 )在恒定的黑暗和12L / 12D的条件下(–0.7 < r <–0.9)处于静止状态(夜间)。总体而言,这些动物表现出原始的体温调节系统,其可能的“设定点”约为33.5°C。

更新日期:2020-11-12
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