With an increasing clinical importance of the treatment of the heart failure (HF) with preserved ejection fraction (HFpEF), it is important to be certain of the diagnosis of HF. We investigated global and regional left ventricular (LV) strains using speckle tracking echocardiography (STE) in patients with HFpEF and compared those parameters with that of patients with hypertension and normal subjects. Peak longitudinal, circumferential and radial strains were assessed globally and regionally for each study groups using STE. Diastolic strain rate was also determined. There were 50 patients in HFpEF group, 56 patients in hypertension group and 46 age-matched normal subjects. In patients with HFpEF, global peak longitudinal, circumferential and radial strain and strain rate were reduced compared to both hypertension patients and normal controls (− 15.5 ± 5.3 vs − 17.7 ± 3.1 and − 19.9 ± 2.0; − 9.7 ± 2.2 vs − 19.3 ± 3.1 and − 20.5 ± 3.3; 17.7 ± 8.2 vs 38.4 ± 12.4 and 43.6 ± 11.9, respectively, P < 0.001, for all). The diagnostic performance of global circumferential strain to predict the HFpEF was greatest among strain parameters (area under the curve = 0.997). In the speckle tracking echocardiography, impaired peak global strain and homogeneously reduced regional strain was observed in HFpEF patients compared to the hypertension patients and normal subjects in decreasing order. This can provide early information on the initiation of LV deformation of HFpEF in patients with hypertension or normal subjects.

中文翻译：

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射血分数保留的心力衰竭患者与高血压患者与年龄匹配对照组的整体和局部心肌应变的比较

随着射血分数保留的心力衰竭 (HF) 治疗的临床重要性日益增加，确定 HF 的诊断很重要。我们使用散斑跟踪超声心动图 (STE) 研究了 HFpEF 患者的全局和区域左心室 (LV) 应变，并将这些参数与高血压患者和正常受试者的参数进行了比较。使用 STE 对每个研究组的纵向、周向和径向应变峰值进行了全球和区域评估。还测定了舒张应变率。HFpEF组50例，高血压组56例，同龄正常人46例。在 HFpEF 患者中，与高血压患者和正常对照组相比，整体峰值纵向、周向和径向应变和应变率均降低 (- 15. 5 ± 5.3 与 − 17.7 ± 3.1 和 − 19.9 ± 2.0；− 9.7 ± 2.2 与 − 19.3 ± 3.1 和 − 20.5 ± 3.3；17.7 ± 8.2 与 38.4 ± 12.4 和 43.6 ± 11.9，分别为 P < 0.001）。整体圆周应变预测 HFpEF 的诊断性能在应变参数中最大（曲线下面积 = 0.997）。在斑点跟踪超声心动图中，与高血压患者和正常受试者相比，HFpEF 患者观察到受损的峰值整体应变和均匀降低的局部应变。这可以提供有关高血压患者或正常受试者 HFpEF LV 变形开始的早期信息。整体圆周应变预测 HFpEF 的诊断性能在应变参数中最大（曲线下面积 = 0.997）。在斑点跟踪超声心动图中，与高血压患者和正常受试者相比，HFpEF 患者观察到受损的峰值整体应变和均匀降低的局部应变。这可以提供有关高血压患者或正常受试者 HFpEF LV 变形开始的早期信息。整体圆周应变预测 HFpEF 的诊断性能在应变参数中最大（曲线下面积 = 0.997）。在斑点跟踪超声心动图中，与高血压患者和正常受试者相比，HFpEF 患者观察到受损的峰值整体应变和均匀降低的局部应变。这可以提供有关高血压患者或正常受试者 HFpEF LV 变形开始的早期信息。