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Determination of the Solubility, Dissolution Enthalpy, and Entropy of Icariin in Acetone, Acetoacetate, Chloroform, and Light Petroleum
Natural Product Communications ( IF 1.8 ) Pub Date : 2020-11-11 , DOI: 10.1177/1934578x20971491
Jiao Xie 1 , Kanghuai Zhang 1 , Haitao Wang 1 , Xin Yang 1 , Wenbin Mao 2 , Chenwei Liu 1 , Na Wang 1
Affiliation  

The solubility of icariin in acetone, acetoacetate, chloroform, and light petroleum in the 283.2‐318.2 K range was measured by ultraviolet-visible spectrophotometry. As the temperature increased, the solubility of icariin in the 4 solvents gradually increased. The solubility data correlated with the modified Apelblat equation. The dissolution enthalpy and entropy of icariin were determined using van’t Hoff plots. The dissolution enthalpy and entropy of icariin in the 4 solvents increases as acetone >acetoacetate >chloroform >light petroleum, which can be explained by the difference of the polarity indices between them. The polarity indices of the solvents affect the solubility behavior.



中文翻译:

番木瓜素在丙酮,乙酰乙酸酯,氯仿和轻质石油中的溶解度,溶解焓和熵的测定

通过紫外可见分光光度法测量了柠檬酸甘油酯在283.2-318.2 K范围内在丙酮,乙酰乙酸酯,氯仿和轻质石油中的溶解度。随着温度升高,二十碳素在四种溶剂中的溶解度逐渐增加。溶解度数据与修改后的Apelblat方程相关。甘草酸的溶解焓和熵通过van't Hoff图确定。随着丙酮>乙酰乙酸盐>氯仿>轻质石油的加入,二十烷酸在4种溶剂中的溶解焓和熵增加,这可以用它们之间极性指数的差异来解释。溶剂的极性指数影响溶解度行为。

更新日期:2020-11-12
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