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Recent developments in autophagy-targeted therapies in cancer
Experimental Biology and Medicine ( IF 3.2 ) Pub Date : 2020-11-09 , DOI: 10.1177/1535370220966545
Manasi P Jogalekar 1 , Anurag Veerabathini 2 , Prakash Gangadaran 3, 4
Affiliation  

Autophagy plays a crucial role in cellular development and differentiation as well as in the maintenance of homeostasis in healthy cells. Autophagy is well documented in neurodegenerative disorders, aging, and infectious diseases. However, recognizing its significance in cancer has always been challenging due to its tumor-promoting and suppressive attributes. Various modulators targeting key components of autophagy machinery directly or indirectly have been developed over the years, and have shown promising results in preclinical models. Some of these compounds are even being tested in clinical trials for safety and efficacy. A detailed review of strategies used to target autophagy in cancer is presented including our opinion on developing better therapies and outstanding issues.



中文翻译:

自噬靶向治疗癌症的最新进展

自噬在细胞发育和分化以及维持健康细胞的稳态中起着至关重要的作用。自噬在神经退行性疾病、衰老和传染病中得到充分证明。然而,由于其促进肿瘤和抑制肿瘤的特性,认识到其在癌症中的重要性一直具有挑战性。多年来,已经开发出多种直接或间接靶向自噬机制关键成分的调节剂,并在临床前模型中显示出有希望的结果。其中一些化合物甚至正在临床试验中进行安全性和有效性测试。详细回顾了用于靶向癌症自噬的策略,包括我们对开发更好的疗法和突出问题的看法。

更新日期:2020-11-12
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