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Cellulose acetate electrospun nanofibers encapsulating Lemon Myrtle essential oil as active agent with potent and sustainable antimicrobial activity
Reactive & Functional Polymers ( IF 5.1 ) Pub Date : 2020-11-11 , DOI: 10.1016/j.reactfunctpolym.2020.104769
Sara Beikzadeh , Alireza Akbarinejad , Simon Swift , Janesha Perera , Paul A. Kilmartin , Jadranka Travas-Sejdic

Highly antibacterial electrospun cellulose acetate (CA) nanofiber mats with encapsulated lemon myrtle essential oil (LMEO) as a natural antibacterial agent were produced. The high antibacterial activity of LMEO was confirmed by minimum inhibitory concentration and the minimum bactericidal concentration analysis. Morphological, thermal, optical, chemical and antimicrobial properties of LMEO-loaded CA electrospun nanofibers were investigated. The morphology of the fiber mat was examined by SEM to study the effect of solvent type, solution viscosity, electrospinning voltage and incorporation of LMEO into the CA electrospun nanofibers. The average diameters of both CA and LMEO-loaded CA nanofibers were in the range of 440–515 nm. The electrospun nanofibers were of a white colour and low water activity. Thermogravimetric analysis indicated no change in degradation profile of CA, while differential scanning calorimetry indicated a lower degree of CA crystallinity upon incorporation of LMEO. The LMEO-loaded CA electrospun nanofibers eliminated Escherichia coli and Staphylococcus aureus by 100% even at the lowest loading concentration of LMEO of 2 wt%. The electrospun fiber mats, with moderate loading of LMEO, showed sustained release of LMEO over prolonged time and nanofibers retained their high antibacterial properties even after two months of storage. Therefore, these nanofibers could be promising candidates for active packaging or wound dressing applications with prolonged antimicrobial activity.



中文翻译:

醋酸纤维素静电纺纳米纤维,囊封柠檬默特尔精油作为活性剂,具有有效且可持续的抗菌活性

制备了高度抗菌的静电纺丝醋酸纤维素(CA)纳米纤维垫,其封装有柠檬默特尔精油(LMEO)作为天然抗菌剂。最低抑菌浓度和最低杀菌浓度分析证实了LMEO的高抗菌活性。研究了负载LMEO的CA电纺纳米纤维的形态,热,光学,化学和抗菌性能。通过SEM检查了纤维毡的形态,以研究溶剂类型,溶液粘度,电纺丝电压以及将LMEO掺入CA电纺纳米纤维中的影响。CA和LMEO负载的CA纳米纤维的平均直径在440-515 nm范围内。电纺纳米纤维为白色且水活度低。热重分析表明CA的降解曲线没有变化,而差示扫描量热法表明掺入LMEO时CA结晶度较低。消除了LMEO负载的CA电纺纳米纤维即使在LMEO的最低负载浓度为2 wt%的情况下,大肠杆菌金黄色葡萄球菌也可以100%的浓度。适度负载LMEO的电纺纤维垫在较长时间内显示出LMEO的持续释放,并且纳米纤维甚至在储存两个月后仍保持了较高的抗菌性能。因此,这些纳米纤维有望成为具有延长抗菌活性的主动包装或伤口敷料应用的有前途的候选者。

更新日期:2020-11-12
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