Hypericum is a genus of flowering plants and presents a nearly worldwide distribution. The relevance of its species is mainly based on the occurrence of specialised secondary metabolites exhibiting a wide range of pharmaceutical and cosmeceutical properties. The most well-reported species in the last decade is H. perforatum, together with its exceptional polycyclic polyprenylated acylphloroglucinols metabolites. Several inhibitory enzyme properties such as anti-tyrosinase, anti-hyaluronidase, anti-collagenase, and anti-elastase, along with the relevant cosmeceutical anti-inflammatory and antimicrobial activities, have been reported in numerous biological studies concerning this genus. From 2010 to date were published more than 3000 articles; therefore, an updated summary of Hypericum species and their related cosmeceutical bioactive compounds is necessary. This detailed analysis will be mainly focused on cosmeceutical-related bioactivity, phytochemical composition, and the products and processes that have been developed using the generated knowledge. Despite all the progress made in recent years, which contributed to a state-of-the-art improvement, only a few studies regarding the genus have been dedicated to investigating the mechanisms of action and the safety (toxicology) of its bioactive compounds using well-validated methodologies. A strategic partnership between R&D and vital cosmeceutical enterprises could be the requisite to promote the development of a higher number of efficient and marketable Hypericum-derived cosmeceutical products.

金丝桃属植物是开花植物的属，并且呈现近乎世界范围的分布。其种类的相关性主要是基于特殊次生代谢物的出现，这些次生代谢物具有广泛的药物和药妆特性。在过去的十年中，报道最多的物种是贯叶连翘（H. perforatum），以及其出色的多环多烯丙基化酰基间苯三酚代谢物。在有关该属的许多生物学研究中，已经报道了几种抑制性酶的性质，例如抗酪氨酸酶，抗透明质酸酶，抗胶原蛋白酶和抗弹性蛋白酶，以及相关的药妆抗炎和抗微生物活性。从2010年至今，已发表了3000多篇文章；因此，金丝桃属植物的更新摘要物种及其相关的药妆生物活性化合物是必需的。这项详细的分析将主要集中在与药妆相关的生物活性，植物化学成分以及使用所产生的知识开发的产品和过程中。尽管近年来取得了所有进展，并为最先进的技术做出了贡献，但有关该属的研究很少，但仍致力于研究其作用机理及其生物活性化合物的安全性（毒理学）。验证的方法。研发与重要的药妆企业之间的战略合作伙伴关系可能是促进开发更多高效和可销售的贯叶连翘来源的药妆产品的必要条件。