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Effects of silver nanoparticles prenatal exposure on rat offspring development
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-11-10 , DOI: 10.1016/j.etap.2020.103546
Aline A. Becaro , Luzia P. de Oliveira , Vera L.S. de Castro , Maria C. Siqueira , Humberto M. Brandão , Daniel S. Correa , Marcos David Ferreira

Many types of nanocomposites employed in food packaging are based on silver nanoparticles (AgNP) because of their antibacterial properties, which can increase food shelf-life. As the commercialization of AgNP products has been expanding, the released of such nanoparticles in the environment has caused enormous concern, once they can pose potential risks to the environment and human beings. For instance, exposure of the maternal environment to nanomaterials during pregnancy may impact the health of the dam, fetus and offspring. In this context, here we investigated the effects of prenatal exposure of AgNP on the pregnancy outcomes of dams and postnatal development of their offspring. Pregnant Wistar rats were exposed to distinct AgNP concentrations (0, 1, 3 and 5 μg/kg/day) from beginning to the end of pregnancy. At parturition, newborns were observed regarding clinical signs of toxicity and survival rate. The offspring was examined by evaluating developmental endpoints. A delay in time for vaginal opening and testes descent were detected in the offspring exposed to AgNP during embryonic development. Our results indicate that prenatal exposure to AgNP can compromise neonatal rats’ postnatal development, especially the reproductive features.



中文翻译:

纳米银的产前暴露对大鼠后代发育的影响

食品包装中使用的许多类型的纳米复合材料均基于银纳米颗粒(AgNP),因为它们具有抗菌特性,可以延长食品的保质期。随着AgNP产品的商业化发展,一旦这种纳米颗粒对环境和人类构成潜在风险,其在环境中的释放就引起了极大的关注。例如,孕妇在孕期将母体环境暴露于纳米材料可能会影响大坝,胎儿和后代的健康。在这种情况下,我们研究了产前暴露于AgNP对大坝妊娠结局及其后代发育的影响。从怀孕开始到结束,怀孕的Wistar大鼠都暴露于不同的AgNP浓度(0、1、3和5μg/ kg /天)。在分娩时 观察新生儿的毒性和存活率的临床迹象。通过评估发育终点检查后代。在胚胎发育过程中,暴露于AgNP的后代中检测到阴道开放和睾丸下降的时间延迟。我们的结果表明,产前暴露于AgNP会损害新生大鼠的产后发育,尤其是生殖功能。

更新日期:2020-11-23
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