Motivated by the complex processes of cellular transport when different types of biological molecular motors can move in opposite directions along protein filaments while also detaching from them, we developed a theoretical model of the bidirectional motion of driven particles. It utilizes a totally asymmetric simple exclusion process framework to analyze the dynamics of particles moving in opposite directions along the lattice of discrete sites while the particles might also dissociate from the filament in the bulk of the system. Mean-field theoretical arguments supported by extensive Monte Carlo simulations are presented in order to understand how the localized particle dissociations affect the bidirectional dynamics and spontaneous symmetry-breaking phenomena. It is found that changes in the amplitudes and in the symmetry of dissociation rates lead to significant modifications in the dynamic properties and in the stationary phase diagrams. These changes are explained using simple physical arguments. Our theoretical method clarifies some aspects of microscopic mechanisms of complex transport phenomena in biological systems. ∗Author to whom any correspondence should be addressed. © 2020 IOP Publishing Ltd and SISSA Medialab srl 1742-5468/20/113202+26$33.00 .S at. M ech. (220) 13202 Effect of local dissociations in bidirectional transport of driven particles

中文翻译：

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局部解离对驱动粒子双向传输的影响

当不同类型的生物分子马达可以沿着蛋白质细丝向相反方向移动，同时也与它们分离时，细胞运输的复杂过程受到启发，我们开发了一个驱动粒子双向运动的理论模型。它利用完全不对称的简单排除过程框架来分析沿离散位点的晶格以相反方向移动的粒子的动力学，而粒子也可能与系统主体中的灯丝分离。提出了广泛的蒙特卡罗模拟支持的平均场理论论证，以了解局部粒子解离如何影响双向动力学和自发对称破坏现象。发现振幅和解离速率对称性的变化导致动态特性和固定相图中的显着修改。使用简单的物理参数来解释这些变化。我们的理论方法阐明了生物系统中复杂传输现象的微观机制的某些方面。∗ 任何信件的收件人。© 2020 IOP Publishing Ltd 和 SISSA Medialab srl 1742-5468/20/113202+26$33.00 .S at. 机械。(220) 13202 局部解离对驱动粒子双向传输的影响 我们的理论方法阐明了生物系统中复杂传输现象的微观机制的某些方面。∗ 任何信件的收件人。© 2020 IOP Publishing Ltd 和 SISSA Medialab srl 1742-5468/20/113202+26$33.00 .S at. 机械。(220) 13202 局部解离对驱动粒子双向传输的影响 我们的理论方法阐明了生物系统中复杂传输现象的微观机制的某些方面。∗ 任何信件的收件人。© 2020 IOP Publishing Ltd 和 SISSA Medialab srl 1742-5468/20/113202+26$33.00 .S at. 机械。(220) 13202 局部解离对驱动粒子双向传输的影响