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Classification of Rhythmic Cortical Activity Elicited by Whole-Body Balance Perturbations Suggests the Cortical Representation of Direction-Specific Changes in Postural Stability
IEEE Transactions on Neural Systems and Rehabilitation Engineering ( IF 4.9 ) Pub Date : 2020-10-06 , DOI: 10.1109/tnsre.2020.3028966 Teodoro Solis-Escalante , Digna De Kam , Vivian Weerdesteyn
IEEE Transactions on Neural Systems and Rehabilitation Engineering ( IF 4.9 ) Pub Date : 2020-10-06 , DOI: 10.1109/tnsre.2020.3028966 Teodoro Solis-Escalante , Digna De Kam , Vivian Weerdesteyn
Postural responses that effectively recover balance following unexpected postural changes need to be tailored to the characteristics of the postural change. We hypothesized that cortical dynamics involved in top-down regulation of postural responses carry information about directional postural changes (i.e., sway) imposed by sudden perturbations to standing balance (i.e., support surface translations). To test our hypothesis, we evaluated the single-trial classification of perturbation-induced directional changes in postural stability from high-density EEG. We analyzed EEG recordings from six young able-bodied individuals and three older individuals with chronic hemiparetic stroke, which were acquired while individuals reacted to low-intensity balance perturbations. Using common spatial patterns for feature extraction and linear discriminant analysis or support vector machines for classification, we achieved classification accuracies above random level (p < 0.05; cross-validated) for the classification of four different sway directions (one vs. the rest scheme). Screening of spectral features (3-50 Hz) revealed that the highest classification performance occurred when low-frequency (3-10 Hz) spectral features were used. Strikingly, the participant-specific classification results were qualitatively similar between young able-bodied individuals and older individuals with chronic hemiparetic stroke. Our findings demonstrate that low-frequency spectral components, corresponding to the cortical theta rhythm, carry direction-specific information about changes in postural stability. Our work presents a new perspective on the cortical representation of postural stability and the possible role of the theta rhythm in the modulation of (directional) reactive balance responses. Importantly, our work provides preliminary evidence that the cortical encoding of direction-specific changes in postural stability is present in chronic hemiparetic stroke.
中文翻译:
由全身平衡扰动引起的节律性皮层活动的分类提示姿势稳定性的特定方向变化的皮层表现
必须针对姿势变化的特征量身定制在有效地恢复意外姿势变化后的平衡的姿势响应。我们假设,自上而下调节姿势反应所涉及的皮质动力学携带着有关突然的扰动对站立平衡(即支撑表面平移)施加的定向姿势变化(即摇摆)的信息。为了检验我们的假设,我们评估了高密度脑电图对扰动引起的姿势稳定性方向变化的单次试验分类。我们分析了六名年轻健全人和三名患有慢性偏中风的老年人的脑电图记录,这些记录是在个人对低强度平衡扰动做出反应时获得的。使用常见的空间模式进行特征提取和线性判别分析,或使用支持向量机进行分类,我们实现了随机水平以上的分类精度(p <0.05;交叉验证),用于四个不同摇摆方向的分类(一个与其他方案) 。频谱特征(3-50 Hz)的筛选显示,当使用低频(3-10 Hz)频谱特征时,分类性能最高。令人惊讶的是,参与者特定的分类结果在年轻健壮的个体和患有慢性偏瘫性中风的老年个体之间在质量上相似。我们的研究结果表明,对应于皮质theta节奏的低频频谱分量携带有关姿势稳定性变化的特定方向信息。我们的工作为姿势稳定性的皮层表征以及theta节奏在(定向)反应性平衡反应的调节中的可能作用提供了新的视角。重要的是,我们的工作提供了初步的证据,表明慢性偏瘫性卒中中存在姿势稳定性特定于方向变化的皮质编码。
更新日期:2020-11-12
中文翻译:
由全身平衡扰动引起的节律性皮层活动的分类提示姿势稳定性的特定方向变化的皮层表现
必须针对姿势变化的特征量身定制在有效地恢复意外姿势变化后的平衡的姿势响应。我们假设,自上而下调节姿势反应所涉及的皮质动力学携带着有关突然的扰动对站立平衡(即支撑表面平移)施加的定向姿势变化(即摇摆)的信息。为了检验我们的假设,我们评估了高密度脑电图对扰动引起的姿势稳定性方向变化的单次试验分类。我们分析了六名年轻健全人和三名患有慢性偏中风的老年人的脑电图记录,这些记录是在个人对低强度平衡扰动做出反应时获得的。使用常见的空间模式进行特征提取和线性判别分析,或使用支持向量机进行分类,我们实现了随机水平以上的分类精度(p <0.05;交叉验证),用于四个不同摇摆方向的分类(一个与其他方案) 。频谱特征(3-50 Hz)的筛选显示,当使用低频(3-10 Hz)频谱特征时,分类性能最高。令人惊讶的是,参与者特定的分类结果在年轻健壮的个体和患有慢性偏瘫性中风的老年个体之间在质量上相似。我们的研究结果表明,对应于皮质theta节奏的低频频谱分量携带有关姿势稳定性变化的特定方向信息。我们的工作为姿势稳定性的皮层表征以及theta节奏在(定向)反应性平衡反应的调节中的可能作用提供了新的视角。重要的是,我们的工作提供了初步的证据,表明慢性偏瘫性卒中中存在姿势稳定性特定于方向变化的皮质编码。