Abstract: Male and female pattern hair loss (MPHL and FPHL, respectively), is the most common cause of hair loss affecting nearly 80 million people in the US, yet treatment options remain limited and lacking. As the need for more effective therapeutics remains unmet, this perspective offers a unique angle by directing attention to the inflammatory aspect of MPHL and FPHL. Evidence and implications of inflammation as a characteristic feature of MPHL and FPHL are highlighted through evaluation of clinical and quantitative data. Comparable results suggest the presence of significant perifollicular inflammatory infiltrates, such as lymphocytes and histiocytes, as well as the involvement of inflammatory genes, such as CASP7 and TNF, in the presentation of MPHL and FPHL. Resurfacing of the inflammatory aspect in MPHL and FPHL pathogenesis will advance future developments in MPHL and FPHL therapeutic options.

Keywords: hair loss, inflammation, male pattern baldness, female pattern baldness


中文翻译：

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男性和女性脱发的炎症方面

摘要：男性和女性型脱发（分别为MPHL和FPHL）是影响美国近8000万人脱发的最常见原因，但治疗选择仍然有限且缺乏。由于对更有效治疗方法的需求尚未得到满足，该观点通过将注意力集中在MPHL和FPHL的炎症方面提供了一个独特的视角。通过评估临床和定量数据，强调了炎症作为MPHL和FPHL的特征的证据和意义。可比较的结果表明存在明显的毛囊周围炎性浸润，例如淋巴细胞和组织细胞，以及炎性基因的参与，例如CASP7和TNF，在MPHL和FPHL的介绍中。MPHL和FPHL发病机制中炎症方面的重新出现将推动MPHL和FPHL治疗选择的未来发展。

关键词：脱发，炎症，男性型秃发，女性型秃发