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The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2020-11-10 , DOI: 10.2147/ijn.s280957
Suelen Cristina Sartoretto 1, 2, 3, 4 , Jose Calasans-Maia 5 , Rodrigo Resende 2, 4, 6 , Eduardo Câmara 3 , Bruna Ghiraldini 7 , Fabio Jose Barbosa Bezerra 8 , Jose Mauro Granjeiro 4, 9 , Monica Diuana Calasans-Maia 4, 6
Affiliation  

Background and Objective: The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep.
Methods: Ten female sheep (2– 4 years) received 30 implants (n=10/group): HAnano® coated (Epikut Plus®, S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX®, Straumann, Basel, Switzerland), and TiUnite (NobelActive®, Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement.
Results: The surface morphology was considerably comparable between the implant groups’; however, the TiUnite® group presented a remarkable different surface. The SLActive® and TiUnite® groups presented an insertion torque average of 74 (± 8.9) N/cm that was similar to that of HAnano® 72 (± 8.3) N/cm (p > 0.05). The resonance frequency evaluated with Osstell®/SmartPeg® or Penguin®/MulTipeg® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p< 0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants.
Conclusion: HAnano® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.

Keywords: osseointegration, dental implant surface, nanotechnology, hydroxyapatite, sheep, bone response


中文翻译:

纳米结构羟基磷灰石表面在骨整合早期的影响:低密度骨的多参数动物研究

背景和目的:据报道,低密度骨种植牙的成功率是一项挑战,特别是在上颌后部区域的早期或即时负荷。纳米级结构会影响植入物的粗糙度、表面积、表面能,并可增强骨整合。本研究旨在评估植入物表面形貌和生物力学、组织形态学和组织学骨对放置在绵羊髂嵴中的新型纳米结构羟基磷灰石表面的反应。
方法: 10 只雌性绵羊(2-4 岁)接受 30 颗植入物(n=10/组):HAnano ®涂层(Epikut Plus ®,SIN Implant System,Sao Paulo,SP,巴西),SLActive (BLX ®, Straumann, Basel, Switzerland) 和 TiUnite (NobelActive ® , Nobel Biocare, Göteborg, Sweden) 表面。使用能量色散光谱的扫描电子显微镜评估了种植体表面形貌,插入扭矩值和共振频率分析评估了种植体植入后 14 天和 28 天后的主要稳定性、骨-种植体接触和骨面积分数占用率。
结果:种植体组之间的表面形态具有相当的可比性。然而,TiUnite ®组呈现出显着不同的表面。SLActive ®和 TiUnite ®组的平均插入扭矩为 74 (± 8.9) N/cm,与 HANano 相似® 72 (± 8.3) N/cm (p > 0.05)。用 Osstell ® /SmartPeg ®或 Penguin ® /MulTipeg ®评估的共振频率在评估同一组的植入物时显示出相似的结果。在整个实验期间,所有组的 BIC 和 BAFO 显着增加 (p<0.05),但同一时间点植入物的 BIC 和 BAFO 值相似。4 周后,骨植入物接触率高于分析总长度的 80%。新骨约占植入物周围分析区域的 60%。
结论: HANano ®涂层表面促进了与绵羊模型中的 SLActive 和 TiUnite 相当的骨整合。在绵羊模型的低密度骨修复早期,三个测试表面显示出相当的骨整合。

关键词:骨整合,牙种植体表面,纳米技术,羟基磷灰石,绵羊,骨反应
更新日期:2020-11-12
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