During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A–C (1–3)] and three known tigliane diterpenoids (4–6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC₅₀ values of 3.8 and 12.8 nM, respectively.

中文翻译：

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来自 Wikstroemia scytophylla 的抗 HIV Tigliane 二萜类化合物

在对Wikstroemia scytophylla进行化学研究期间，分离出了三种新的 [wikstrocins A–C ( 1 – 3 )] 和三种已知的 tigliane 二萜 ( 4 – 6 )。通过广泛的物理化学和光谱分析阐明了新化合物的结构。还评估了 ECD Cotton 效应与 tiglianes B 环结构之间的相关性。评估了分离的化合物对MT4细胞的HIV-1感染的抗HIV活性，两种化合物（4和6）显示出有效的抗HIV活性，IC ₅₀值分别为3.8和12.8 nM。