Anjana Rao describes the team effort to define the changes in chromatin accessibility in naive T cells during TH1 and TH2 cell differentiation after stimulation with TCR ligands and the appropriate cytokines. Her lab showed that differentiated TH1 and TH2 cells, which produce the cytokines IFN-γ and IL-4, respectively, displayed distinct patterns of DNase I hypersensitivity, histone acetylation and NFAT1 transcription factor binding around the Ifng and Il4 genes. This project turned them into a ‘real’ immunology lab!

中文翻译：

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科学分歧：从信号传导和转录到 T 细胞中的染色质变化

Anjana Rao 描述了团队努力定义在 TCR 配体和适当细胞因子刺激后 TH1 和 TH2 细胞分化过程中幼稚 T 细胞染色质可及性的变化。她的实验室表明，分化的 TH1 和 TH2 细胞分别产生细胞因子 IFN-γ 和 IL-4，在 Ifng 和 Il4 基因周围显示出不同的 DNase I 超敏反应、组蛋白乙酰化和 NFAT1 转录因子结合模式。这个项目把他们变成了一个“真正的”免疫学实验室！