A nickel-catalyzed cross-electrophile coupling reaction between (hetero)aryl bromides and 2,2-difluorovinyl tosylate is presented. This protocol provides facile incorporation of the gem-difluorovinyl moiety in organic molecules. The method features mild reaction conditions, good functional group tolerance, and excellent yields. Furthermore, mechanistic experiments and DFT studies indicate a Ni(0)/Ni(II) catalytic cycle, thus differing from the currently accepted catalytic cycle for nickel-catalyzed C(sp²)–C(sp²) cross-electrophile coupling reactions.

中文翻译：

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镍催化的跨亲电偶合反应合成宝石-二氟乙烯基芳烃

提出了镍催化的（杂）芳基溴化物与2，2-二氟乙烯基甲苯磺酸酯之间的亲电子交联反应。该方案提供了在有机分子中宝石-二氟乙烯基部分的容易掺入。该方法具有温和的反应条件，良好的官能团耐受性和优异的收率。此外，机理实验和DFT研究表明Ni（0）/ Ni（II）催化循环，因此不同于当前接受的镍催化的C（sp ²）–C（sp ²）亲电子偶联反应的催化循环。