当前位置: X-MOL 学术J. Spinal Cord Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Tetraplegic obstructive sleep apnoea patients dilate the airway similarly to able-bodied obstructive sleep apnoea patients
The Journal of Spinal Cord Medicine ( IF 1.7 ) Pub Date : 2020-11-09 , DOI: 10.1080/10790268.2020.1829418
Alice Hatt 1 , Elizabeth Brown 1, 2 , David J Berlowitz 3, 4 , Fergal O'Donoghue 3, 4, 5 , Hailey Meaklim 3 , Alan Connelly 5 , Graeme Jackson 5 , Kate Sutherland 6, 7 , Peter A Cistulli 6, 7 , Bon San Bonne Lee 1, 2 , Lynne E Bilston 1, 8
Affiliation  

Context/objective: Obstructive sleep apnoea (OSA) develops soon after cervical spinal cord injury (SCI) at rates higher than the general population, but the mechanisms are not understood. This study aimed to determine whether OSA in SCI is associated with altered pharyngeal muscle dilatory mechanics during quiet breathing, as has been observed in the non-SCI injured with obstructive sleep apnoea.

Design: Cross sectional imaging study.

Setting: Medical research institute.

Participants: Eight cervical SCI patients with OSA were recruited and compared to 13 able-bodied OSA patients and 12 able-bodied healthy controls of similar age and BMI.

Interventions and outcome measures: 3T MRI scans of upper airway anatomy and tagged-MRI to characterize airway muscle motion during quiet breathing were collected for analysis.

Results: Considerable variation in the patterns of inspiratory airway muscle motion was observed in the SCI group, with some participants exhibiting large inspiratory airway dilatory motions, and others exhibiting counterproductive narrowing during inspiration. These patterns were not dissimilar to those observed in the able-bodied OSA participants. The increase in airway cross-sectional area of able-bodied control participants was proportional to increase in BMI, and a similar, but not significant, relationship was present in all groups.

Conclusion: Despite the limited sample size, these data suggest that SCI OSA patients have heterogeneous pharyngeal dilator muscle responses to the negative pressures occurring during inspiration but, as a group, appear to be more similar to able-bodied OSA patients than healthy controls of similar age and BMI. This may reflect altered pharyngeal pressure reflex responses in at least some people with SCI.



中文翻译:

四肢瘫痪阻塞性睡眠呼吸暂停患者的气道扩张与健全的阻塞性睡眠呼吸暂停患者相似

背景/目标:阻塞性睡眠呼吸暂停 (OSA) 在颈脊髓损伤 (SCI) 后不久以高于一般人群的发病率发展,但其机制尚不清楚。本研究旨在确定 SCI 中的 OSA 是否与安静呼吸期间改变的咽肌扩张力学有关,正如在阻塞性睡眠呼吸暂停的非 SCI 损伤中观察到的那样。

设计:横断面成像研究。

地点:医学研究所。

参与者:招募了 8 名患有 OSA 的颈椎 SCI 患者,并与 13 名身体健全的 OSA 患者和 12 名年龄和 BMI 相似的身体健全的健康对照者进行了比较。

干预措施和结果测量:收集上呼吸道解剖结构的 3T MRI 扫描和标记 MRI 以表征安静呼吸期间的气道肌肉运动以进行分析。

结果:在 SCI 组中观察到吸气气道肌肉运动模式的显着变化,一些参与者表现出较大的吸气气道扩张运动,而另一些参与者在吸气期间表现出适得其反的狭窄。这些模式与在健全的 OSA 参与者中观察到的模式没有什么不同。健全的对照组参与者气道横截面积的增加与 BMI 的增加成正比,并且在所有组中都存在相似但不显着的关系。

_年龄和体重指数。这可能反映了至少一些 SCI 患者的咽部压力反射反应改变。

更新日期:2020-11-09
down
wechat
bug