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Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
Virulence ( IF 5.2 ) Pub Date : 2020-11-11 , DOI: 10.1080/21505594.2020.1845039
Ansel Hsiao 1 , Jun Zhu 2
Affiliation  

ABSTRACT

The Gram-negative bacterium Vibrio cholerae is responsible for the severe diarrheal pandemic disease cholera, representing a major global public health concern. This pathogen transitions from aquatic reservoirs into epidemics in human populations, and has evolved numerous mechanisms to sense this transition in order to appropriately regulate its gene expression for infection. At the intersection of pathogen and host in the gastrointestinal tract lies the community of native gut microbes, the gut microbiome. It is increasingly clear that the diversity of species and biochemical activities within the gut microbiome represents a driver of infection outcome, through their ability to manipulate the signals used by V. cholerae to regulate virulence and fitness in vivo. A better mechanistic understanding of how commensal microbial action interacts with V. cholerae pathogenesis may lead to novel prophylactic and therapeutic interventions for cholera. Here, we review a subset of this burgeoning field of research.



中文翻译:

霍乱弧菌在宿主-肠道微生物组相互作用界面的致病性和毒力调节

摘要

革兰氏阴性细菌霍乱弧菌是严重腹泻性流行病霍乱的罪魁祸首,是全球主要的公共卫生问题。这种病原体从水生宿主转变为人群中的流行病,并进化出许多机制来感知这种转变,以便适当调节其感染的基因表达。胃肠道中病原体和宿主的交汇处存在着天然肠道微生物群落,即肠道微生物组。越来越清楚的是,肠道微生物组内物种和生化活动的多样性是感染结果的驱动因素,因为它们能够操纵霍乱弧菌使用的信号来调节体内的毒力和适应。更好地了解共生微生物的作用如何与霍乱弧菌发病机制相互作用,可能会带来新的霍乱预防和治疗干预措施。在这里,我们回顾了这个新兴研究领域的一个子集。

更新日期:2020-11-12
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