ABSTRACT

Cell migration is a highly dynamic and energy-intensive process that ensures the correct targeting of cells during embryonic and postnatal development. In recent work, we highlighted the importance of macroautophagy/autophagy in regulating the dynamics of cell migration under baseline conditions and in response to a diverse set of molecular factors. Genetic suppression of autophagy-related genes induced longer stationary phases in migrating cells and cell stalling at the beginning of the migratory stream. We also showed that autophagy is required for recycling of the focal adhesion molecule PXN (paxillin), and is induced by energy levels of cells via AMPK activation. This recent study revealed the importance of autophagy in the maintenance of cell migration, and showed that the dynamic interplay between autophagy and energy levels is required to sustain neuronal migration and to cope with diverse micro-environmental factors.

摘要

细胞迁移是一个高度动态和能量密集的过程，可确保在胚胎和出生后发育过程中正确靶向细胞。在最近的工作中，我们强调了巨自噬/自噬在调节基线条件下细胞迁移动态和响应多种分子因素方面的重要性。自噬相关基因的遗传抑制在迁移细胞中诱导更长的静止期和在迁移流开始时的细胞停滞。我们还表明自噬是黏着斑分子 PXN（桩蛋白）的再循环所必需的，并且通过 AMPK 激活由细胞的能量水平诱导。最近的这项研究揭示了自噬在维持细胞迁移中的重要性，