当前位置: X-MOL 学术Synthesis › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent Advances in One-Pot Enyne Metathesis Processes for the Preparation of Biologically and Medicinally Relevant Compounds
Synthesis ( IF 2.6 ) Pub Date : 2020-11-09 , DOI: 10.1055/s-0040-1705965
Massimo Serra 1 , Eric Bernardi , Lino Colombo
Affiliation  

Enyne metathesis reactions are powerful tools for the preparation of a wide range of synthetic and natural chemical substances with increasing efficiency and environmental sustainability. The driving force of the reaction is the formation of a stable conjugated system, i.e., a diene, which through further functionalization steps can be used for the construction of skeletally complex molecular architectures. These concepts are exploited to design cascade reaction sequences, where multiple rings can be formed in a one-pot fashion by combining metathetic protocols with various chemical transformations. The strong correlation between synthetic organic chemistry and medicinal chemistry prompted us to review the most notable approaches for the synthesis of biologically relevant compounds via enyne metathesis-based one-pot processes. With the aim to provide a modern and practical overview, by taking into consideration the scientific literature on this topic, we have focused the majority of our attention on the research performed in the last decade. This review covers the literature from 2003 to 2020.

1 Introduction

2 Ethylene-Mediated Processes

3 RCEYM/CM and CEYM/RCM Processes

4 Enyne Metathesis/Diels–Alder-Based Processes

5 RCM of Dienynes

6 RCM of Tethered Dienynes

7 Relay Metathesis

8 Ring-Rearrangement Metathesis

9 RCEYM/Transition-Metal-Catalyzed C–C Bond-Forming Processes

10 Conclusions

11 List of Acronyms



中文翻译:

一锅法烯炔复分解过程制备生物和药物相关化合物的最新进展

烯炔复分解反应是制备各种合成和天然化学物质的有力工具,可提高效率和环境可持续性。反应的驱动力是形成稳定的共轭体系,即二烯,其通过进一步的官能化步骤可用于构建骨架复杂的分子结构。利用这些概念来设计级联反应序列,在该级联反应序列中,通过将易位方案与各种化学转化相结合,可以一锅法形成多个环。合成有机化学和药物化学之间的密切相关性促使我们回顾了通过基于烯炔复分解的一锅法合成生物相关化合物的最著名方法。为了提供现代和实用的概述,通过考虑有关该主题的科学文献,我们将大部分注意力集中在了过去十年中进行的研究上。这篇综述涵盖了2003年至2020年的文献。

1引言

2乙烯介导的工艺

3 RCEYM / CM和CEYM / RCM流程

4 Enyne复分解/狄尔斯-基于der木的过程

Dienynes的5 RCM

系留二烯的6 RCM

7中继复分解

8环重排复分解

9 RCEYM /过渡金属催化的C–C键形成过程

10结论

11缩略语列表

更新日期:2020-11-12
down
wechat
bug