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Prophage-Dependent Neighbor Predation Fosters Horizontal Gene Transfer by Natural Transformation
mSphere ( IF 4.8 ) Pub Date : 2020-11-11 , DOI: 10.1128/msphere.00975-20
Roberto C Molina-Quiroz 1 , Triana N Dalia 2 , Andrew Camilli 3 , Ankur B Dalia 4 , Cecilia A Silva-Valenzuela 5
Affiliation  

Natural transformation is a broadly conserved mechanism of horizontal gene transfer (HGT) in bacteria that can shape their evolution through the acquisition of genes that promote virulence, antibiotic resistance, and other traits. Recent work has established that neighbor predation via type VI secretion systems, bacteriocins, and virulent phages plays an important role in promoting HGT. Here, we demonstrate that in chitin estuary microcosms, Vibrio cholerae K139 lysogens exhibit prophage-dependent neighbor predation of nonlysogens to enhance HGT. Through predation of nonlysogens, K139 lysogens also have a fitness advantage under these microcosm conditions. The ecological strategy revealed by our work provides a better understanding of the evolutionary mechanisms used by bacteria to adapt in their natural setting and contributes to our understanding of the selective pressures that may drive prophage maintenance in bacterial genomes.

中文翻译:

依赖噬菌体的邻居捕食通过自然转化促进水平基因转移

自然转化是细菌水平基因转移 (HGT) 的一种广泛保守的机制,它可以通过获得促进毒力、抗生素抗性和其他特征的基因来塑造它们的进化。最近的工作已经确定,通过 VI 型分泌系统、细菌素和有毒噬菌体的邻居捕食在促进 HGT 中起着重要作用。在这里,我们证明了在几丁质河口微观世界中,霍乱弧菌K139 溶原菌表现出非溶原菌的前噬菌体依赖性邻居捕食以增强 HGT。通过捕食非溶原菌,K139 溶原菌在这些微观条件下也具有适应性优势。我们的工作揭示的生态策略提供了对细菌用于适应其自然环境的进化机制的更好理解,并有助于我们理解可能驱动细菌基因组中原噬菌体维持的选择压力。
更新日期:2020-11-12
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