当前位置: X-MOL 学术Bioeng. Transl. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Engineered macrophage membrane‐enveloped nanomedicine for ameliorating myocardial infarction in a mouse model
Bioengineering & Translational Medicine ( IF 7.4 ) Pub Date : 2020-11-10 , DOI: 10.1002/btm2.10197
Yugang Xue 1 , Guangwei Zeng 2 , Jin Cheng 1 , Jianqiang Hu 1 , Mingming Zhang 1 , Yan Li 1
Affiliation  

Myocardial infarction (MI) is the serious condition causing lots of death over the world. Myocytes apoptosis, inflammation, and fibrosis are three important factors implicated in pathogenesis of MI. Targeting these three factors has been shown to ameliorate MI and rescue cardiac function. Previous studies have demonstrated that microRNA (miR) 199a‐3p protect against MI. In this study, we prepare macrophage membrane coated nanoparticles (MMNPs) containing miR199a‐3p. We evaluate the effects of these NPs on apoptosis and cell proliferation in vitro and the effects on inflammation cytokine production, expression of fibrosis related proteins, cardiac injuries, and functions in MI mice. We find that the MMNPs have receptors of interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor alpha (TNF‐α) and can bind to these cytokines. MMNPs prevent hypoxia‐induced apoptosis and promote cell proliferation, suppress the inflammation, and inhibit the cardiac fibrosis in MI mice. These results demonstrate that MMNPs ameliorate left ventricular remodeling and cardiac functions, and protect against MI, suggesting MMNPs containing miR199a‐3p is a potential therapeutic approach to treat MI.

中文翻译:

工程化巨噬细胞膜包裹纳米药物可改善小鼠模型中的心肌梗塞

心肌梗塞(MI)是导致世界范围内大量死亡的严重疾病。心肌细胞的凋亡,炎症和纤维化是与MI发病有关的三个重要因素。针对这三个因素已表明可改善心肌梗死并挽救心脏功能。先前的研究表明,microRNA(miR)199a-3p可以预防MI。在本研究中,我们制备了含有miR199a-3p的巨噬细胞膜包被的纳米颗粒(MMNP)。我们评估这些NPs对体外细胞凋亡和细胞增殖的影响以及对MI小鼠炎症细胞因子产生,纤维化相关蛋白表达,心脏损伤和功能的影响。我们发现MMNP具有白介素-1β(IL-1β),白介素-6(IL-6)和肿瘤坏死因子α(TNF-α)的受体,并且可以与这些细胞因子结合。MMNP可预防MI小鼠缺氧诱导的细胞凋亡并促进细胞增殖,抑制炎症和抑制心脏纤维化。这些结果表明MMNP可改善左心室重塑和心脏功能,并可预防MI,这表明含miR199a-3p的MMNP是治疗MI的潜在治疗方法。
更新日期:2020-11-10
down
wechat
bug