In inguinal adipose tissue, beige adipocytes are interspersed among white adipocytes and in close communication with dynamic populations of immune cells. Recent data have demonstrated that anti‐inflammatory macrophages (M2) increase thermogenic activity of beige adipocytes, although the mechanism is currently under debate. ILC2, cells via secretion, of methionine enkephalin peptide were found to be able to increase beige thermogenesis. Knights et al. have recently generated a whole‐body knock‐out of KLF3 (KLF3‐/‐) to explore its contribution to thermogenesis and weight gain in a diet‐induced obesity animal model.

中文翻译：

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脂肪组织中的嗜酸性粒细胞能火上浇油吗？

在腹股沟脂肪组织中，米色脂肪细胞散布在白色脂肪细胞中，并与动态的免疫细胞群密切联系。最近的数据表明，抗炎巨噬细胞 (M2) 会增加米色脂肪细胞的产热活性，尽管目前该机制尚存在争议。发现通过分泌蛋氨酸脑啡肽的细胞 ILC2 能够增加米色产热。骑士等。最近产生了 KLF3 (KLF3-/-) 的全身敲除，以探索其在饮食诱导的肥胖动物模型中对产热和体重增加的贡献。