Natural modifications of cellular RNA include various chemical modifications, such as N6‐methyladenosine (m⁶A), which enable the orderly metabolism and function of RNA structural diversity, thereby affecting gene expression. Spermatogenesis is a complex differentiating developmental process, which includes the proliferation of spermatogonial stem cells, spermatocyte meiosis and sperm maturation. Emerging evidence has shown that RNA methylation can influence RNA splicing, exportation and translation, which are controlled in the male germline in order to ensure coordinated gene expression. In this review, we summarize the typical characteristics of different types of RNA methylation during the process of spermatogenesis. In particular, we emphasize the functions of the RNA methylation effectors during the male germ cell development.

中文翻译：

---

精子发生过程中 RNA 甲基化的异常调节

细胞 RNA 的自然修饰包括各种化学修饰，例如N6-甲基腺苷(m ⁶A)，使 RNA 结构多样性的有序代谢和功能，从而影响基因表达。精子发生是一个复杂的分化发育过程，包括精原干细胞增殖、精母细胞减数分裂和精子成熟。新出现的证据表明，RNA 甲基化可以影响 RNA 剪接、输出和翻译，这些在雄性生殖系中受到控制，以确保协调的基因表达。在这篇综述中，我们总结了精子发生过程中不同类型 RNA 甲基化的典型特征。我们特别强调了在雄性生殖细胞发育过程中 RNA 甲基化效应子的功能。