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Hemodynamic response varies across tactile stimuli with different temporal structures
Human Brain Mapping ( IF 4.8 ) Pub Date : 2020-11-10 , DOI: 10.1002/hbm.25243
Luyao Wang 1, 2 , Chunlin Li 3 , Duanduan Chen 4 , Xiaoyu Lv 1, 2 , Ritsu Go 1, 2 , Jinglong Wu 1, 2, 5 , Tianyi Yan 2, 4
Affiliation  

Tactile stimuli can be distinguished based on their temporal features (e.g., duration, local frequency, and number of pulses), which are fundamental for vibrotactile frequency perception. Characterizing how the hemodynamic response changes in shape across experimental conditions is important for designing and interpreting fMRI studies on tactile information processing. In this study, we focused on periodic tactile stimuli with different temporal structures and explored the hemodynamic response function (HRF) induced by these stimuli. We found that HRFs were stimulus‐dependent in tactile‐related brain areas. Continuous stimuli induced a greater area of activation and a stronger and narrower hemodynamic response than intermittent stimuli with the same duration. The magnitude of the HRF increased with increasing stimulus duration. By normalizing the characteristics into topographic matrix, nonlinearity was obvious. These results suggested that stimulation patterns and duration within a cycle may be key characters for distinguishing different stimuli. We conclude that different temporal structures of tactile stimuli induced different HRFs, which are essential for vibrotactile perception and should be considered in fMRI experimental designs and analyses.

中文翻译:

不同时间结构的触觉刺激的血流动力学反应不同

可以根据触觉刺激的时间特征(例如,持续时间、局部频率和脉冲数)来区分触觉刺激,这些是振动触觉频率感知的基础。表征血液动力学响应如何在实验条件下改变形状对于设计和解释触觉信息处理的 fMRI 研究很重要。在这项研究中,我们专注于具有不同时间结构的周期性触觉刺激,并探讨了这些刺激引起的血流动力学响应函数 (HRF)。我们发现 HRF 在与触觉相关的大脑区域中依赖于刺激。与具有相同持续时间的间歇性刺激相比,连续刺激诱导了更大的激活区域和更强和更窄的血流动力学反应。HRF 的幅度随着刺激持续时间的增加而增加。通过将特征归一化为地形矩阵,非线性很明显。这些结果表明,刺激模式和周期内的持续时间可能是区分不同刺激的关键特征。我们得出结论,触觉刺激的不同时间结构会诱导不同的 HRF,这对于振动触觉感知至关重要,应在 fMRI 实验设计和分析中加以考虑。
更新日期:2021-01-19
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