Pre‐ovulatory mature follicles are not readily induced from gonadotropin (Gn)‐independent early follicles in the poor ovarian response (POR) state, characterized by reduced number of retrieved oocytes. Bone morphogenetic protein (BMP), which is expressed in the ovary, contributes to early folliculogenesis, but its precise underlying mechanism remains unknown. The purpose of this study was to examine the effects of BMP‐2 on granulosa cells (GCs) of Gn‐independent early follicles.

中文翻译：

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骨形态发生蛋白-2 通过鞘氨醇激酶 1 促进促性腺激素非依赖性卵泡发育

处于不良卵巢反应 (POR) 状态的促性腺激素 (Gn) 非依赖性早期卵泡不容易诱导排卵前成熟卵泡，其特征是回收卵母细胞数量减少。在卵巢中表达的骨形态发生蛋白 (BMP) 有助于早期卵泡发生，但其确切的潜在机制仍然未知。本研究的目的是检查 BMP-2 对 Gn 非依赖性早期卵泡颗粒细胞 (GC) 的影响。