Aims

It has been shown that periodontitis, can be modified by systemic changes, including behavioral factors, such as diet. Caloric restriction is one of the dietary therapeutic strategies indicated for obesity. It is associated with several benefits, among them, modulation of the inflammatory response. The aim of this study was to verify whether caloric restriction in obese rats changes the progression of experimental ligature-induced periodontitis.

Materials and methods

Forty-eight Wistar rats were used for 24 weeks and initially fed with cafeteria diet during 12 weeks. The animals were divided into four groups according to the caloric restriction and experimental periodontitis. The cotton thread was placed around the mandibular first molars, for 15 days, before the end of the experiment. Rats submitted to caloric restriction received, from the 13th week of the experimental protocol, 70% of the food intake compared to the ad libitum animals of other study of the our research group. Alveolar bone loss was assessed using macroscopic morphometric analysis. Analyzes of clinical periodontal measures, biometrics, serum biomarkers and biochemical parameters were performed.

Key findings

Caloric restriction decreased the alveolar bone loss in the periodontitis group when compared to the group that received a cafeteria diet with periodontitis. Moreover, the results demonstrate the improvement in the glycemic profile, without prejudice to bone tissue biomarkers.

Significance

Based on the results, caloric restriction reduces the progression of alveolar bone loss in rats with experimental periodontitis, in addition to presenting benefits in biometric data, decreasing both glycemic profile and clinical periodontal measures.

中文翻译：

---

热量限制可防止肥胖大鼠实验性牙周炎中牙槽骨的丢失

目的

研究表明，牙周炎可以通过全身性改变来改变，包括行为因素，例如饮食。热量限制是肥胖症的饮食治疗策略之一。它与多种益处相关，其中包括调节炎症反应。这项研究的目的是验证肥胖大鼠的热量限制是否会改变实验性结扎诱导的牙周炎的进展。

材料和方法

使用48只Wistar大鼠24周，最初在12周内用食堂饮食喂养。根据热量限制和实验性牙周炎将动物分为四组。在实验结束前，将棉线放在下颌第一磨牙周围15天。与实验组其他研究中的自由采食动物相比，从实验方案的第13周起，接受热量限制的大鼠的摄食量为70％。使用宏观形态分析评估牙槽骨丢失。进行了临床牙周测量，生物测定，血清生物标志物和生化参数的分析。

主要发现

与接受食堂饮食并患有牙周炎的组相比，牙周炎组的热量限制减少了牙槽骨的损失。此外，结果表明在不损害骨组织生物标志物的情况下改善了血糖曲线。

意义

根据这些结果，热量限制可以减少实验性牙周炎大鼠的牙槽骨丢失，此外还可以提高生物识别数据的优势，同时降低血糖水平和临床牙周措施。