Celiac disease (CD) is an immune-mediated disease that develops in genetically susceptible individuals upon gluten exposure. Human Leukocyte Antigen (HLA) genes in the Major Histocompatibility Complex (MHC) have been described to represent the 40% of the genetic risk to develop CD. Aiming to gain understanding of the genetic involvement in CD, high throughput studies have been performed, revealing that many CD-associated variants are located in non-coding regions, hindering the study of the functional implications of these single nucleotide polymorphisms (SNPs). In the last decade, long non-coding RNAs (lncRNAs) have been described to be influenced by disease-associated SNPs and to drive many important mechanisms involved in the development of inflammatory diseases. Here we describe the lncRNAs identified and characterized in the context of celiac disease and highlight the importance of the study of these molecules in inflammatory and autoimmune disorders.

乳糜泻 (CD) 是一种免疫介导的疾病，在接触麸质后在遗传易感个体中发展。主要组织相容性复合体 (MHC) 中的人类白细胞抗原 (HLA) 基因已被描述为代表 40% 的发生 CD 的遗传风险。为了了解 CD 中的遗传参与，已经进行了高通量研究，揭示了许多 CD 相关变体位于非编码区，阻碍了对这些单核苷酸多态性 (SNP) 的功能意义的研究。在过去十年中，长链非编码 RNA (lncRNA) 被描述为受疾病相关 SNP 的影响，并驱动许多参与炎症性疾病发展的重要机制。