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Development and validation of an HPLC-DAD method for the simultaneous identification and quantification of Topotecan, Irinotecan, Etoposide, Doxorubicin and Epirubicin
Arabian Journal of Chemistry ( IF 6 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.arabjc.2020.11.002
Seydou Sanogo , Paolo Silimbani , Raffaella Gaggeri , Carla Masini

Abstract The knowledge of the chemical stability of drugs prepared and administered in hospital is of paramount importance for establishing the methods and times of their preparation, as well as for ensuring patient safety. The objective of this work was to develop and validate a single chromatographic method, according to the International Conference on Harmonization (ICH), United States Pharmacopeia (USP) and the European Pharmacopoeia (Ph. Eur.) guidelines, to allow the determination of the chemical stability of 5 chemotherapy drugs. The high performance liquid chromatography coupled with diode array detection (HPLC-DAD) method developed was found to be linear (all analytical curves showed R2 ≥ 0.999), sensitive, precise (RSDs

中文翻译:

用于同时鉴定和定量拓扑替康、伊立替康、依托泊苷、多柔比星和表柔比星的 HPLC-DAD 方法的开发和验证

摘要 了解在医院制备和给药的药物的化学稳定性对于确定其制备方法和时间以及确保患者安全至关重要。这项工作的目的是根据国际协调会议 (ICH)、美国药典 (USP) 和欧洲药典 (Ph. Eur.) 指南,开发和验证单一色谱方法,以允许确定5种化疗药物的化学稳定性。发现开发的高效液相色谱联用二极管阵列检测 (HPLC-DAD) 方法是线性的(所有分析曲线均显示 R2 ≥ 0.999)、灵敏、精确(RSD
更新日期:2021-01-01
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