The classification of insecticide resistance in sand flies populations is based on concepts and methodologies used to characterize the susceptibility profile in mosquitoes. This can generate erroneous and subjective interpretations since they are biologically different organisms. In this context, the goal of this review is to analyze the works and/or articles that aimed at characterizing the susceptibility of sand flies and describing the methodological parameters, in order to improve future works to estimate more accurately the resistance of sand flies to insecticides. Using keywords that refer to the purpose of this review, scientific studies in English, Spanish and Portuguese published until December 2019 were analyzed. A total of 3481 articles were found in searches in four databases (Pubmed, Scopus, BVS and ScienceDirect) and 61 were selected. The panorama of sand-fly resistance revealed 47 populations of sand flies, of species Phlebotomus papatasi, Ph. argentipes e Sergentomyia shorttii, with confirmed resistance, and 28 populations of species Ph. papatasi, Ph. argentipes, Ph. sergenti e Lutzomyia longipalpis. Of the 61 selected studies, only three studies performed comparisons between field and colony phlebotomines, and all colony populations were less susceptible than field populations to at least one tested insecticide. The lethal doses and lethal times of sand flies are very varied, revealing that there is no specific protocol for assessing the susceptibility of sand flies to insecticides. For a quick and early detection of sand flies’ resistance to insecticides, we suggest the use of CDC bottle tests with an SRL to estimate the local Dose and Diagnostic Time. Males and females can be used in the same proportion, but with only female sand flies in the control group. Females with engorged abdomen or pregnant should be avoided in the experiment and, if possible, use the F1 generation of field sand flies, up to 5 days old, or at least 100 sand flies to reduce the influence of age on the susceptibility of the population.

沙蝇种群对杀虫剂的抗性分类基于用于表征蚊子易感性的概念和方法。由于它们是生物学上不同的生物，因此会产生错误和主观的解释。在这种情况下，本综述的目的是分析旨在表征沙蝇易感性并描述方法学参数的工作和/或文章，以改进未来的工作以更准确地估计沙蝇对杀虫剂的抗性。使用了指向本评价目的的关键字，分析了截至2019年12月以英文，西班牙文和葡萄牙文出版的科学研究。在四个数据库（Pubmed，Scopus，BVS和ScienceDirect）的搜索中总共找到3481篇文章，并且选择了61篇。确诊具有抗药性的巴氏石竹（Phlebotomus papatasi，Argentipes e Sergentomyia shorttii）和28个物种的巴氏木瓜（Ph。papatasi），Argentipes，Ph.sergenti e Lutzomyia longipalpis。在所选择的61项研究中，只有三项研究比较了田间和菌落phlebotomines，并且所有菌落种群都比田间种群对至少一种测试杀虫剂的敏感性较低。沙蝇的致死剂量和致死时间变化很大，这表明尚无评估沙蝇对杀虫剂敏感性的具体方案。为了快速及早发现沙蝇对杀虫剂的抗性，我们建议使用带有SRL的CDC瓶检验来估计当地的剂量和诊断时间。雄性和雌性的使用比例相同，但对照组中仅雌性沙蝇。在实验中应避免腹部充血或怀孕的雌性，如果可能的话，使用F1代实地沙蝇，最长达5天，