It proved that the most destructive effects of the toxic Al³⁺ ion on the human nervous system and disease that are involved with this system, such as Alzheimer's. The development of solid-state electrodes is still in its infancy during the sensor-based detection methods for Al³⁺. Hence, in this study, a novel flexible ITO/PET-based electrochemical solid-state sensor was designed and constructed. Modification of the surface of electrode bedding was done by layer-by-layer (LbL) assembly of Mg–Al LDH. nanoplatelets along with alizarin red S (ARS) in an interconnected matrix film. In the molecular design of sensing base of the electrode, the electroactive organic units (ARS molecules) present in the ITO/PET-layered (ARS/LDHs)_n matrix are involved in electrochemical reactions when exposed to the target molecule (Al³⁺ ion), so the electrochemical changes of the new formed Al-chelated system are detectable. This type of sensor is used for sensitive and selective detection of Al³⁺. The minimum sheet resistance, morphology and high electrocatalytic activity of the modified matrix film are obtained in the fifth cycle of LbL assembly technique. In this electrochemical sensor, both electrochemical and optical methods were detected with high sensitivity and selectivity of Al³⁺, so that in a cyclic voltammetry electrochemical method, the lower detection limit of 10.1 nM with a linear range of [0.2–120 μM] was obtained compared to the fluorescence-based optical method.

事实证明，有毒的Al ³⁺离子对人类神经系统和与该系统有关的疾病（例如阿尔茨海默氏病）的破坏力最大。在基于传感器的Al ³⁺探测方法中，固态电极的发展仍处于起步阶段。因此，在这项研究中，设计和构造了一种新型的基于ITO / PET的柔性电化学固态传感器。通过Mg–Al LDH的逐层（LbL）组装完成了电极垫层的表面改性。相互连接的基质膜中的纳米血小板和茜素红S（ARS）。在电极传感基体的分子设计中，ITO / PET层（ARS / LDHs）中存在的电活性有机单元（ARS分子）_n基质暴露于目标分子（Al ³⁺离子）时会参与电化学反应，因此可以检测到新形成的Al螯合体系的电化学变化。这种类型的传感器用于Al ^3+的灵敏和选择性检测。在LbL组装技术的第五个循环中获得了改性基质膜的最小薄层电阻，形态和高电催化活性。在该电化学传感器中，以高灵敏度和高选择性的Al ³⁺进行了电化学和光学方法的检测，因此在循环伏安法电化学方法中，线性范围为[0.2–120μM]的下限为10.1 nM。与基于荧光的光学方法相比获得的结果。