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Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions
Molecular Biology Reports ( IF 2.8 ) Pub Date : 2020-11-10 , DOI: 10.1007/s11033-020-05963-w
R. Karthiya , S. Mohammed Wasil , Piyush Khandelia

Post-transcriptional chemical modification of RNA is rapidly emerging as a key player in regulating gene expression and has propelled the development of ‘epitranscriptomics’ or ‘RNA epigenetics’ as a frontier area of research. Several RNA modifications are known to decorate RNAs and impact its structure and function. One such recently discovered modification is acetylation of RNA i.e. N4-acetylcytidine (ac4C) chemical modification. N4-acetylcytidine is an ancient and evolutionarily conserved modification, which maps to a wide spectrum of RNAs from archaea bacteria to humans. This modification results in a variety of functional outcomes which impact normal development and disease. In this review, we summarize the recent progress, emerging methods, biological implications and the future challenges for ac4C modification.



中文翻译:

RNA的N4-乙酰胞苷修饰在基因调控和细胞功能中的新兴作用

RNA的转录后化学修饰正迅速成为调节基因表达的关键因素,并推动了“上皮组学”或“ RNA表观遗传学”的发展,成为研究的前沿领域。已知几种RNA修饰可修饰RNA,并影响其结构和功能。一种这样最近发现的修饰是RNA的乙酰化,即N4-乙酰胞苷(ac4C)化学修饰。N4-乙酰胞苷是一种古老且进化上保守的修饰,可映射到从古细菌到人类的各种RNA。这种修饰导致影响正常发育和疾病的各种功能结果。在这篇综述中,我们总结了ac4C修饰的最新进展,新兴方法,生物学意义和未来挑战。

更新日期:2020-11-12
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