Selenium (Se) is an essential micronutrient with antioxidative properties, but previous studies have shown that extremely high circulating Se concentrations are associated with a higher prevalence of cardiovascular diseases (CVDs). To date, it remains unknown whether this association has connections with arterial calcification. A total of 982 participants with both serum Se concentration and abdominal aortic calcification (AAC) score data were enrolled from the 2013-2014 National Health and Nutrition Examination Survey (NHANES), a cross-sectional study of a noninstitutionalized population in the USA. Serum Se levels were determined by inductively coupled plasma-dynamic reaction cell-mass spectrometry. AAC was obtained from dual-energy X-ray absorptiometry and quantified by the Kauppila score system. Severe AAC was defined as Kauppila score ≥ 5. Among all participants, the mean serum Se level was 132.89 μg/L. The average AAC score was 1.51, and 11.7% had severe AAC. Compared with those in the lowest quartile of Se (< 121.1 μg/L), the highest quartile subgroup (> 143.1 μg/L) was associated with a higher mean AAC score (β-coefficient 0.88; 95% CI 0.28, 1.47; p = 0.004) and greater odds of having severe AAC (odds ratio 2.19; 95% CI 1.10, 4.36; p = 0.026) after adjusting for demographic, biochemical, and clinical characteristics. The concentrations of other circulating trace elements showed no statistically significant association with the AAC score. High serum Se levels were independently associated with an increased mean AAC score and aggravated AAC severity among noninstitutionalized US adults. Serum Se might adversely affect the cardiovascular system when the serum Se concentration exceeds 143 μg/L.

中文翻译：

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血清硒水平与腹主动脉钙化的临床相关性。

硒 (Se) 是一种具有抗氧化特性的必需微量营养素，但之前的研究表明，极高的循环硒浓度与心血管疾病 (CVD) 的患病率较高有关。迄今为止，尚不清楚这种关联是否与动脉钙化有关。共有 982 名具有血清硒浓度和腹主动脉钙化 (AAC) 评分数据的参与者参加了 2013-2014 年国家健康和营养检查调查 (NHANES)，这是一项针对美国非机构化人群的横断面研究。血清硒水平通过电感耦合等离子体动态反应细胞质谱法测定。AAC 是从双能 X 射线吸收测定法中获得的，并通过 Kauppila 评分系统进行量化。重度 AAC 定义为 Kauppila 评分 ≥ 5。在所有参与者中，平均血清硒水平为 132.89 μg/L。平均 AAC 得分为 1.51，11.7% 的人患有重度 AAC。与 Se 最低四分位数 (< 121.1 μg/L) 的亚组相比，最高四分位数亚组 (> 143.1 μg/L) 与更高的平均 AAC 评分相关（β 系数 0.88；95% CI 0.28, 1.47；p = 0.004) 并且在调整人口统计学、生化和临床特征后，患重度 AAC 的几率更大（比值比 2.19；95% CI 1.10，4.36；p = 0.026）。其他循环微量元素的浓度与 AAC 评分没有统计学上的显着关联。在非机构化的美国成年人中，高血清硒水平与平均 AAC 评分增加和 AAC 严重程度增加独立相关。