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T cell factor 1: A master regulator of the T cell response in disease
Science Immunology ( IF 24.8 ) Pub Date : 2020-11-06 , DOI: 10.1126/sciimmunol.abb9726
Giulia Escobar 1 , Davide Mangani 1 , Ana C Anderson 1
Affiliation  

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.



中文翻译:

T 细胞因子 1:疾病中 T 细胞反应的主要调节因子

最近的进展重新定义了 T 细胞因子 1 (TCF1) 的作用,它超越了 T 细胞发育和 T 记忆形成,并包含了调节 T 细胞生物学的新功能。在这里,我们讨论了 TCF1 在外周 T 细胞中的多方面和上下文相关的作用,特别是在疾病诱导的炎症状态,如自身免疫、癌症和慢性感染。了解 TCF1 如何微调外周 T 细胞生物学具有定制改进免疫靶向疗法的潜力。

更新日期:2020-11-09
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