The synthesis of (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted phenyl/H-pyrazol-3-yl)-amines and (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl/cinnamoyl-pyrazol-3-yl)-amines by conventional heating and microwave irradiative cyclocondensation have been achieved by the cyclisation of N-(4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-3-oxo butyramide with substituted hydrazines and acid hydrazides. The required butyramide has been synthesized by the reaction of 2,4-diamino-6-methyl-[1,3,5]-triazine with benzaldehyde followed by the condensation with ethyl acetoacetate. Structural elucidation of synthesized compounds has been performed by IR, ¹H NMR and mass spectral studies besides chemical transformation and elemental analysis. The title compounds have been evaluated for their antitubercular and antimicrobial potential against some selected microorganisms to establish the structure activity relationship.

中文翻译：

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常规加热和微波辐射环缩合反应合成三嗪键合的吡唑杂环并评估其抗结核和抗菌潜力

（4-亚苄基氨基-6-甲基-[1,3,5]-三嗪-2-基）-（5-甲基-2-取代的苯基/ H-吡唑-3-基）-胺和（4的合成-亚苄基氨基-6-甲基-[1,3,5]-三嗪-2-基）-（5-甲基-2-取代的苯甲酰基/异二十二酰基/肉桂酰基-吡唑-3-基）-胺，通过常规加热和微波辐射通过将N-（4-亚苄基氨基-6-甲基-[1,3,5]-三嗪-2-基）-3-氧代丁酰胺与取代的肼和酰肼环化，可实现环缩合。通过2，4-二氨基-6-甲基-[1,3,5]-三嗪与苯甲醛反应，然后与乙酰乙酸乙酯缩合反应，合成了所需的丁酰胺。合成化合物的结构解析已通过IR，^1完成1 H NMR和质谱研究以及化学转化和元素分析。已经评估了标题化合物针对某些选定微生物的抗结核和抗微生物潜力，以建立结构活性关系。