We herein developed a new class of carborhodamines (CRs), i.e. 10-methoxy-substituted carborhodamines MCRs, by a simple synthesis procedure, which have absorption and emission wavelengths longer than classical CRs while retaining their excellent photophysical properties. Based on the MCR platform, we constructed the mitochondria-targeted fluorescent probe MCR-DMA and demonstrated its potential for sensing singlet oxygen (¹O₂) in living cells during the photodynamic therapy process.

中文翻译：

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一类新型碳硼丹明的设计，合成和生物成像应用

我们通过简单的合成方法在本文中开发了一种新型的碳硼丹明胺（CR），即10-甲氧基取代的碳硼丹明MCR，其吸收和发射波长比经典CR长，同时保留了其出色的光物理性质。基于MCR平台，我们构建了针对线粒体的荧光探针MCR-DMA，并展示了其在光动力疗法过程中检测活细胞中单线态氧（¹ O ₂）的潜力。