Systemic mastocytosis, characterized by infiltration of multiple organs by neoplastic mast cells, is a well-described entity in human medicine with specific criteria for diagnosis, but is ill defined in veterinary literature. Hemostatic disorders are reported in humans affected by systemic mastocytosis but have not been well described in veterinary literature. A 5-y-old, spayed female Greyhound dog had a 1-mo history of progressive ventral cutaneous edema, hemorrhage, and pain. Cytology of an antemortem aspirate from the subcutis of the ventral abdomen was suggestive of mast cell neoplasia, but no discrete mass was present. The dog was euthanized and submitted for autopsy; marked subcutaneous edema and hemorrhage were confirmed. The ventral abdominal panniculus and dermis superficial to the panniculus carnosus were infiltrated by a dense sheet of neoplastic mast cells. The neoplastic cells contained toluidine blue–positive granules and formed aggregates within the bone marrow and several visceral organs, including the liver, spleen, heart, and kidney. Diffuse edema and hemorrhage is an unusual presentation of mast cell tumors in dogs. Antemortem tests, including complete blood count, coagulation profile, and viscoelastic coagulation testing, were suggestive of a primary hemostatic defect. We discuss here the diagnostic criteria used in humans, how these can be applied to veterinary patients, and the limitations of the current diagnostic framework.

系统性肥大细胞增多症，其特征是肿瘤性肥大细胞浸润多个器官，在人类医学中是一个很好描述的实体，具有特定的诊断标准，但在兽医文献中定义不明确。据报道，受系统性肥大细胞增多症影响的人类会出现止血障碍，但在兽医文献中没有得到很好的描述。一只 5 岁、已绝育的雌性灵缇犬有 1 个月的进行性腹侧皮肤水肿、出血和疼痛病史。来自腹侧腹部皮下组织的死前抽吸物的细胞学提示肥大细胞瘤形成，但不存在离散的肿块。这只狗被安乐死并提交尸检；确认有明显的皮下水肿和出血。腹侧腹部脂膜和肉膜表层真皮被致密的肿瘤性肥大细胞片浸润。肿瘤细胞含有甲苯胺蓝阳性颗粒，并在骨髓和几个内脏器官（包括肝、脾、心和肾）内形成聚集体。弥漫性水肿和出血是犬肥大细胞肿瘤的一种不寻常表现。死前检查，包括全血细胞计数、凝血曲线和粘弹性凝血试验，提示有原发性止血缺陷。我们在此讨论用于人类的诊断标准，如何将这些标准应用于兽医患者，以及当前诊断框架的局限性。肿瘤细胞含有甲苯胺蓝阳性颗粒，并在骨髓和几个内脏器官（包括肝、脾、心和肾）内形成聚集体。弥漫性水肿和出血是犬肥大细胞肿瘤的一种不寻常表现。死前检查，包括全血细胞计数、凝血曲线和粘弹性凝血试验，提示有原发性止血缺陷。我们在此讨论用于人类的诊断标准，如何将这些标准应用于兽医患者，以及当前诊断框架的局限性。肿瘤细胞含有甲苯胺蓝阳性颗粒，并在骨髓和几个内脏器官（包括肝、脾、心和肾）内形成聚集体。弥漫性水肿和出血是犬肥大细胞肿瘤的一种不寻常表现。死前检查，包括全血细胞计数、凝血曲线和粘弹性凝血试验，提示有原发性止血缺陷。我们在此讨论用于人类的诊断标准，如何将这些标准应用于兽医患者，以及当前诊断框架的局限性。和粘弹性凝血试验，均提示原发性止血缺陷。我们在此讨论用于人类的诊断标准，如何将这些标准应用于兽医患者，以及当前诊断框架的局限性。和粘弹性凝血试验，均提示原发性止血缺陷。我们在此讨论用于人类的诊断标准，如何将这些标准应用于兽医患者，以及当前诊断框架的局限性。