The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.

生物钟控制着哺乳动物生理学的多个方面，并协调生物过程和行为的日常振荡。我们的昼夜节律由大脑中的内源性中央时钟驱动，该时钟与周围组织的时钟同步，从而调节我们的免疫系统和感染的严重程度。这些节律影响治疗剂和疫苗的药代动力学和功效。核心昼夜节律调节回路和时钟调节宿主途径为识别新型抗病毒疗法提供了肥沃的土壤。进一步了解昼夜节律系统在调节病毒感染和宿主对病毒的反应中所起的作用将为我们对这些疾病的临床管理提供信息。这篇综述概述了生物钟与病毒感染之间相互作用的实验和临床证据报告，强调了病毒钟研究的重要性。