An experimental novel antiaging intervention strategy is based on the concept of parabiosis, which involves long-term treatment with factors derived from young blood facilitating rejuvenation of old individuals. In this study, we employed blood plasma from young rats as an intervention strategy to evaluate whether this could impact aging biomarkers in aged rats. The biomarkers studied include: reactive oxygen species, the ferric reducing ability of plasma, plasma membrane redox system, reduced glutathione, malondialdehyde, protein carbonyl, and advanced oxidation protein products in blood. Additionally, the level of tumor necrosis factor-α and interleukin-6 were also estimated in blood. We found that old rats injected with plasma from young rats were protected from oxidative stress. Thus, this study provides some evidence of the rejuvenating effects of young plasma. We hypothesize that young plasma may contain certain “factors,” which may be responsible for the observed effects. The mechanism of action is not clearly understood and is open to further studies.

中文翻译：

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将年轻大鼠的血浆注射到老年大鼠体内诱导抗衰老作用

一种实验性的新型抗衰老干预策略基于联体共生的概念，其中涉及使用来自年轻血液的因子进行长期治疗，以促进老年人的恢复活力。在这项研究中，我们使用年轻大鼠的血浆作为干预策略来评估这是否会影响老年大鼠的衰老生物标志物。研究的生物标志物包括：活性氧、血浆中的铁还原能力、质膜氧化还原系统、还原型谷胱甘肽、丙二醛、蛋白质羰基和血液中的高级氧化蛋白质产物。此外，还评估了血液中肿瘤坏死因子-α和白细胞介素-6的水平。我们发现注射了年轻大鼠血浆的老年大鼠可以免受氧化应激。因此，这项研究为年轻血浆的恢复活力提供了一些证据。我们假设年轻的血浆可能包含某些“因素”，这可能是造成观察到的影响的原因。作用机制尚不清楚，有待进一步研究。