The brain generates negative prediction error (NPE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing learned behaviors when they are no longer useful. Neurons encoding NPE have been reported in multiple brain regions. Here, we use an optogenetic approach to demonstrate that GABAergic cerebello-olivary neurons can generate a powerful NPE signal, capable of causing extinction of conditioned motor responses on its own.

中文翻译：

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负预测误差的小脑-橄榄信号足以引起联想运动学习的消失

大脑产生负预测错误（NPE）信号以触发灭绝，这是一种抑制性学习，负责在不再有用时抑制已学习的行为。已经报道了在多个脑区域中编码NPE的神经元。在这里，我们使用光遗传学方法来证明GABA能的小脑-橄榄神经元可以产生强大的NPE信号，从而能够自行导致条件性运动反应的消失。