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Are p-values Useful to Judge the Evidence Against the Null Hypotheses in Complex Clinical Trials? A Comment on ”The Role of p-values in Judging the Strength of Evidence and Realistic Replication Expectations”
Statistics in Biopharmaceutical Research ( IF 1.8 ) Pub Date : 2020-11-09 Martin Posch, Franz König
中文翻译:
p值对判断复杂临床试验中无效假设的证据有用吗?评述“ p值在判断证据和现实复制期望强度中的作用”
更新日期:2020-11-09
Statistics in Biopharmaceutical Research ( IF 1.8 ) Pub Date : 2020-11-09 Martin Posch, Franz König
Abstract
In this comment on Eric Gibson's comprehensive paper on "The role of p-values in judging the strength of evidence and realistic replication expectations" we extend the discussion on the use of p-values to judge the strength of evidence to complex clinical trials. We adress adjusted p-values for group sequential and adaptive trials, trials with multi treatment arms, endpoints and subgroups as well as platform trials.
中文翻译:
p值对判断复杂临床试验中无效假设的证据有用吗?评述“ p值在判断证据和现实复制期望强度中的作用”
摘要
在对埃里克·吉布森(Eric Gibson)关于“ p值在判断证据强度和现实复制期望的作用中的作用”的综合性论文的评论中,我们将对使用p值判断证据强度的讨论扩展到了复杂的临床试验。我们为小组顺序试验和适应性试验,具有多种治疗方案的试验,终点和亚组以及平台试验获得调整后的p值。