ABSTRACT

Introduction

Intrahepatic cholangiocarcinomas (iCCA) are aggressive tumors, often diagnosed in advanced stages and with limited curative treatment options. Their incidence has raised in the past years, increasing their associated economic burden. This study aimed to measure hospital incidence and mortality of iCCA and to evaluate direct medical costs.

Methods

Records of admissions due to iCCA between 1 January 2000 and 31 December 2018 were obtained from a Spanish National discharge database. Hospital incidence and mortality were measured within the hospitalized population and medical costs were assessed for specialized healthcare.

Results

Admission files corresponded to 23,315 patients, with a median age of 73 years (IQR = 17) and 55.9% of males. Cholangiocarcinoma presented a hospital incidence of 6.9 per 10,000 persons in 2018, increasing significantly over the study period. In-hospital mortality was 31.5% in the year 2018 and remained stable over the study period. The mean annual direct medical cost of secondary care was €9417 per patient in the year 2017, and increased significantly between 2000 and 2008, stabilizing after 2009.

Conclusion

The incidence of iCCA in Spain increased over the past years. The medical costs of iCCA per patient stabilized after 2008 but total costs are expected to increase if incidence continues to raise.

中文翻译：

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西班牙肝内胆管癌住院发病率及直接医疗费用分析（2000-2018）

摘要

介绍

肝内胆管癌 (iCCA) 是侵袭性肿瘤，通常在晚期被诊断出来，治疗选择有限。他们的发病率在过去几年有所增加，增加了相关的经济负担。本研究旨在衡量 iCCA 的医院发病率和死亡率，并评估直接医疗费用。

方法

2000 年 1 月 1 日至 2018 年 12 月 31 日期间因 iCCA 入院的记录来自西班牙国家出院数据库。在住院人群中测量医院发病率和死亡率，并评估专门医疗保健的医疗费用。

结果

入院档案对应 23,315 名患者，中位年龄为 73 岁 (IQR = 17)，男性占 55.9%。2018 年胆管癌的住院发病率为每 10,000 人 6.9 例，在研究期间显着增加。2018 年的住院死亡率为 31.5%，并且在研究期间保持稳定。2017 年二级医疗的平均年度直接医疗费用为每位患者 9417 欧元，2000 年至 2008 年间显着增加，2009 年后趋于稳定。

结论

西班牙 iCCA 的发病率在过去几年有所增加。iCCA 每名患者的医疗费用在 2008 年后趋于稳定，但如果发病率继续上升，预计总费用会增加。