Abstract

This study investigated the effect of potato peel extract (PPE), orally administrated to rabbits, on serum blood metabolites and ameliorating oxidative stress induced by cold stress under Egyptian winter conditions. Twenty-four bucks grouped into three treatments (8 animals per group) were used for the experiment. The animals received 1.5 ml of water orally, containing 0 (PPE0), 25 (PPE25) or 50 (PPE50) mg PPE/kg live weight. Bucks were randomly assigned into three homogenous equal groups according to the level of PPE. Treatments were applied to each animal every two days over a period of three months including one month as an adaptation period. At the 8th week of the experiment, blood samples were collected from each buck and at the end of the experiment, bucks were slaughtered, and some organs were collected and weighed. The PPE improved (p < 0.05) blood total protein, albumin, globulin and glucose. The blood concentration of total lipid, cholesterol, triglyceride, low density lipoprotein and very low-density lipoprotein (were increased (p < 0.02) in PPE rabbits. Furthermore, PPE extract doses decreased (p < 0.001) oxidant thiobarbituric reactive substance (TBARS) in both blood and liver. Other liver and blood antioxidant system enzymes such as catalase, glutathione peroxidase, and superoxide dismutase were improved (p < 0.005) by PPE supplementation. Overall, oral administration of PPE up to 50 mg/kg live weight can have positive effects on rabbit health under cold stress.

摘要

本研究调查了给兔子口服马铃薯皮提取物 (PPE) 对血清血液代谢物和改善埃及冬季条件下冷应激引起的氧化应激的影响。将 24 美元分为三个处理组（每组 8 只动物）用于实验。动物口服 1.5 ml 水，含有 0 (PPE0)、25 (PPE25) 或 50 (PPE50) mg PPE/kg 活重。根据个人防护装备的水平，雄鹿被随机分配到三个同质相等的组中。在三个月的时间里每两天对每只动物进行一次治疗，包括一个月的适应期。在实验的第8周，从每只公鹿身上采集血样，在实验结束时宰杀公鹿，采集一些器官并称重。个人防护装备改善（p  < 0.05) 血液总蛋白、白蛋白、球蛋白和葡萄糖。PPE 兔的总脂质、胆固醇、甘油三酯、低密度脂蛋白和极低密度脂蛋白的血液浓度（增加（p  < 0.02）。此外，PPE 提取物的剂量减少（p  < 0.001）氧化剂硫代巴比妥反应物质（TBARS）在血液和肝脏中。其他肝脏和血液抗氧化系统酶，如过氧化氢酶、谷胱甘肽过氧化物酶和超氧化物歧化酶通过补充 PPE 得到改善 ( p  < 0.005)。总体而言，口服 PPE 高达 50 mg/kg 活体重可以冷应激下对兔子健康的积极影响。