ABSTRACT Dietary modification may improve quality of life and fatigue severity in Multiple Sclerosis (MS) patients. Given this, there is a growing interest in healthy diets, especially Mediterranean based. The goal of this study was to explore the effects of a modified Mediterranean (mMeD) dietary intervention in Quality Of Life (QOL), and severity of fatigue in MS participants. About 180 Relapsing-Remitting MS patients randomly assigned to follow/not follow the mMeD for 6 months. Primary endpoints were related to dietary adherence and study completion. Clinical endpoints were evaluated Multiple Sclerosis Quality Of Life-54 items, Fatigue Severity Scale (FSS-9), and Visual Analog Fatigue Scale. Data were analyzed by SPSS 24. Of 261 screened patients (July 2018–February 2019), 180 were eligible and willing to commit. 68/90 as mMeD and 79/90 as control group completed the study. Self-reported adherence was excellent (95%). The majority of mean changes for QOL were statistically significant (P < .001). As well, Mean change on the FSS-9 was −9.8 ± 11.5 compared to +0.3 ± 4.2 for controls (P < .001). This regimen improved fatigue and some components of QOL in RRMS patients. Larger scale and longer duration trials to assess the role of diet as a disease modifier in MS should be conducted.

中文翻译：

---

改良地中海饮食改善多发性硬化症患者生活质量和疲劳严重程度的潜力：一项单中心随机对照试验

摘要 饮食调整可以改善多发性硬化症 (MS) 患者的生活质量和疲劳程度。鉴于此，人们对健康饮食的兴趣日益浓厚，尤其是地中海饮食。本研究的目的是探索改良的地中海 (mMeD) 饮食干预对 MS 参与者的生活质量 (QOL) 和疲劳严重程度的影响。大约 180 名复发缓解型 MS 患者被随机分配为遵循/不遵循 mMeD 6 个月。主要终点与饮食依从性和研究完成有关。临床终点通过多发性硬化生活质量 54 项、疲劳严重程度量表 (FSS-9) 和视觉模拟疲劳量表进行评估。数据通过 SPSS 24 进行分析。 在 261 名筛查患者中（2018 年 7 月至 2019 年 2 月），180 名符合条件并愿意承诺。68/90 作为 mMeD 和 79/90 作为对照组完成了研究。自我报告的依从性非常好 (95%)。QOL 的大多数平均变化具有统计学意义（P < .001）。同样，FSS-9 的平均变化为 -9.8 ± 11.5，而对照组为 +0.3 ± 4.2 (P < .001)。该方案改善了 RRMS 患者的疲劳和 QOL 的某些组成部分。应该进行更大规模和更长持续时间的试验，以评估饮食作为 MS 疾病调节剂的作用。