Abstract

Several types of cutaneous fungal infections can affect the population worldwide, such as dermatophytosis, cutaneous candidiasis, onychomycosis, and sporotrichosis. However, oral treatments have pronounced adverse effects, making the topical route an alternative to avoid this disadvantage. On the other hand, currently available pharmaceutical forms designed for topical application, such as gels and creams, do not demonstrate effective retention of biomolecules in the upper layers of the skin. An interesting approach to optimise biomolecules’ activity in the skin is the use of nanosystems for drug delivery, especially solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), which in the past decade has shown advantages like increased adhesiveness, great occlusive properties and higher biomolecule deposition in stratum corneum when designed for topical application. Considering the demand for more effective therapeutic alternatives and the promising characteristics of SLN and NLC for topical application, the present study sought to gather studies that investigated the potential of using SLN and NLC for the treatment of cutaneous fungal infections. Studies demonstrated that these nanosystems showed optimisation, mostly, of the effectiveness of biomolecules besides other biopharmaceutical properties, in addition to offering potential occlusion and hydration of the applied region.

摘要

几种类型的皮肤真菌感染可以影响全世界的人口，例如皮肤癣菌病，皮肤念珠菌病，灰指甲和孢子体病。然而，口服治疗具有明显的不利影响，使得局部途径成为避免该缺点的替代方案。另一方面，设计用于局部应用的当前可用的药物形式，例如凝胶和乳膏，没有表现出生物分子在皮肤上层中的有效保留。优化皮肤中生物分子活性的一种有趣方法是使用纳米系统进行药物输送，尤其是固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC），它们在过去十年中显示出诸如增加粘合性，专为局部应用而设计时，具有良好的闭塞性和较高的生物分子在角质层中的沉积。考虑到对更有效的治疗替代方法的需求以及局部应用SLN和NLC的有前途的特性，本研究寻求收集一些研究，以研究使用SLN和NLC治疗皮肤真菌感染的潜力。研究表明，这些纳米系统除提供其他潜在的封堵作用和水合作用外，还显示出生物分子除其他生物药物特性外的有效性最优化。本研究试图收集一些研究，以研究使用SLN和NLC治疗皮肤真菌感染的可能性。研究表明，这些纳米系统除提供其他潜在的封堵作用和水合作用外，还显示出生物分子除其他生物药物特性外的有效性最优化。本研究试图收集一些研究，以研究使用SLN和NLC治疗皮肤真菌感染的可能性。研究表明，这些纳米系统除提供其他潜在的封闭和水合作用外，还显示出生物分子除其他生物药物特性外的有效性得到了优化。