Gastric ulcers are common in horses. The purpose of this study was to test the effect of porcine hydrolysed collagen (PHC) on gastric ulcer scores and gastric juice pH in horses. We hypothesise that PHC-administration will result in improved gastric lesion scores and act synergistically with omeprazole to improve treatment efficacy. Thoroughbred horses (n = 10) were studied in a 2-period, 2-treatment crossover design, where the PHC (45 g) was administered twice daily. Horses were treated for 56 days. Gastroscopy was performed and gastric juice pH measured on Days 0, 14, 28, 42, 49 and 56. Nonglandular gastric ulcer number (NGN) and severity (NGS) and glandular ulcer number (GN) and glandular severity (GS) scores were assigned by an investigator masked to treatment and serum gastrin and amino acid concentrations. By Day 42, 2 weeks after discontinuing omeprazole treatment, NGN and NGS scores returned to pretreatment values and serum gastrin was higher when compared to values measured on Day 28. By Day 49, after the feed-deprivation period, NGN and NGS were similar to pretreatment values. By Day 56, mean NGN score was significantly lower in PHC-treated horses, compared to controls. Mean gastric juice pH significantly increased in both groups on Day 28 and the pH was significantly (P = 0.0127) higher in the PHC-treated horses. Serum amino acid concentrations were not significantly different 2 h after feeding PHC and hydroxyproline was not detected. Serum gastrin concentration did not increase 2 h after feeding in the PHC-fed horses. The PHC fed to horses enhanced the effects of omeprazole on increased gastric juice pH, inhibited gastrin secretion after feeding and resulted in fewer nonglandular ulcers after long-term feeding (56 days) in stall-confined horses undergoing intermittent feeding.

中文翻译：

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猪水解胶原蛋白对马胃溃疡评分、胃液 pH 值、胃泌素和氨基酸浓度的影响

胃溃疡在马身上很常见。本研究的目的是测试猪水解胶原蛋白 (PHC) 对马胃溃疡评分和胃液 pH 值的影响。我们假设 PHC 给药将导致胃损伤评分改善，并与奥美拉唑协同作用以提高治疗效果。纯种马 (n = 10) 在 2 周期、2 治疗交叉设计中进行了研究，其中 PHC (45 g) 每天施用两次。马被处理了56天。在第 0、14、28、42、49 和 56 天进行胃镜检查并测量胃液 pH 值。分配非腺性胃溃疡数 (NGN) 和严重程度 (NGS) 以及腺性溃疡数 (GN) 和腺体严重程度 (GS) 评分由一位不知道治疗和血清胃泌素和氨基酸浓度的研究人员进行。到第 42 天，停止奥美​​拉唑治疗 2 周后，NGN 和 NGS 评分恢复到治疗前值，与第 28 天测量的值相比，血清胃泌素更高。到第 49 天，在断食期后，NGN 和 NGS 与治疗前值相似。到第 56 天，与对照组相比，经 PHC 治疗的马的平均 NGN 评分显着降低。在第 28 天，两组的平均胃液 pH 值显着增加，PHC 处理的马的 pH 值显着升高（P = 0.0127）。喂食 PHC 后 2 小时血清氨基酸浓度无显着差异，未检测到羟脯氨酸。在喂食 PHC 的马后 2 小时，血清胃泌素浓度没有增加。喂给马的 PHC 增强了奥美拉唑对增加胃液 pH 值的影响，