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Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds
Macromolecular Materials and Engineering ( IF 3.9 ) Pub Date : 2020-11-09 , DOI: 10.1002/mame.202000529
Manon Minsart 1 , Arn Mignon 1 , Aysu Arslan 1 , Iain U. Allan 2 , Sandra Van Vlierberghe 1 , Peter Dubruel 1
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Malodorous wounds have a detrimental effect on the patient's well‐being. A dressing combining the properties of hydrogels and activated carbon (AC) would be beneficial for the treatment of these wounds, controlling wound exudate while adsorbing malodor‐causing compounds. The present work involves the use of acrylate‐endcapped, urethane‐based precursors (AUPs) and methacrylated alginate (AlgMOD). AUPs are synthesized with a varying poly(ethylene glycol) backbone molar mass (2–20 kg mol−1) to tune mechanical and swelling properties, whereas methacrylated alginate, known for its hemostatic properties, enables chemical cross‐linking. Blends of AUP and AlgMOD with AC are processed into hydrogel sheets and electrospun membranes. The results indicate tunable mechanical (Young's moduli 0.03–0.63 MPa) and swelling properties (2.2–34.9 gwater g h y d r o g e l 1 ) along with high gel fractions (>85%). The sheets are compared with commercial odor‐adsorbing dressings (Carbonet and Carboflex), enabling benchmarking. AUP sheets (8 and 10 kg mol−1) containing 0.5% w/w AC show strong adsorption (>90% after 24 h) of crystal violet. The obtained (core–shell AlgMOD/AUP) fibers are visualized using scanning and transmission electron microscopy. Indirect cell tests reveal the developed materials to be biocompatible. In conclusion, a hydrogel‐based odor‐adsorbing wound dressing is successfully synthesized and holds promise for malodorous wound healing.

中文翻译:

含活性炭的PEG基水凝胶作为新型候选敷料,用于治疗恶臭伤口

恶臭的伤口会对患者的健康产生不利影响。结合了水凝胶和活性炭(AC)特性的敷料将有利于治疗这些伤口,控制伤口渗出液,同时吸附引起恶臭的化合物。目前的工作涉及丙烯酸酯封端的氨基甲酸酯前体(AUPs)和甲基丙烯酸藻酸盐(AlgMOD)的使用。合成的AUP具有不同的聚乙二醇主链摩尔质量(2-20 kg mol -1)以调节机械性能和溶胀性能,而以其止血性能着称的甲基丙烯酸海藻酸酯则可以实现化学交联。将AUP和AlgMOD与AC的共混物加工成水凝胶片和电纺膜。结果表明可调节的机械强度(杨氏模量为0.03–0.63 MPa)和溶胀特性(2.2–34.9 g G H ÿ d [R Ø G Ë - 1个 )以及较高的凝胶分数(> 85%)。将该床单与商业气味吸收敷料(Carbonet和Carboflex)进行比较,从而进行基准测试。含有0.5%w / w AC的AUP纸(8和10 kg mol -1)显示出强烈的结晶紫吸附(24小时后> 90%)。使用扫描和透射电子显微镜观察获得的(核壳AlgMOD / AUP)纤维。间接细胞测试表明,开发的材料具有生物相容性。总之,成功地合成了基于水凝胶的气味吸收伤口敷料,并有望治愈恶臭伤口。
更新日期:2021-01-16
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